Drug Targeting And Delivery: Concepts In Dosage Form Design

Front Cover
H.E. Junginger
CRC Press, Oct 31, 1992 - Medical - 300 pages
This is a review of the structure and function of biological membranes and other cellular barriers used in drug transport. It discusses a range of concepts for drug delivery systems, treating the routes of drugs with regard to their characteristics: function, structure, uptake, mechanism and effect. The book also explores the interface between pharmaceutical technology and physiological principles in drug design, a field of increased importance to industry.
 

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Contents

Receptordependent uptake of macromolecules by specific hepatic cells
13
Novel immunoliposome targeting system avoiding reticuloendothelial cell
26
Structure and barrier function of the epithelium of gastrointestinal
45
Colloidal drug delivery systems for gastrointestinal application
71
Intestinal bioadhesive drug delivery systems
92
Oral uptake of microparticles across the gastrointestinal mucosa
113
basic physiology and its use for replacement
129
Molecular aspects of lung surfactant proteins and their use as pulmonal
155
DERMAL ANDTRANSDERMAL ROUTES
169
reconstructed skin as a tool in the development
178
Trends in transdermal drug delivery systems
190
Interactions between liposomes and human stratum corneum in vitro
203
Nasal membranesstructure and permeability
223
Present and future trends in pharmaceutical dosage forms for nasal
237
Index
247
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