Drug Addiction: Morphine, sedative/hypnotic and alcohol dependence. 1, Volume 2
This volume addresses the general problem of drug addiction from several points of view, which are in some ways quite unique and different from other areas of pharmacology. Drug addiction is closely associated with criminal behavior. One of the great and noble edifices of civilization is the philosophic and ethical view that man is perfectible, and some believe that this can be achieved by providing the appropriate circumstance or environment in which man can mature and be educated. Some have postulated that drug abuse is a consequence of an inadequate or pathologic set of socializing experiences or is a consequence of basic conflicts between the values and accepted patterns of behavior of a subculture and that of a larger culture. The degree to which man is malleable and perfectible by social forces is not known nor do we know the true desirability of socializing individuals to the extent that their behavior does not deviate from social norms. Some deviancy is essential for innovation and creativity, and at times there may be difficulties in determining whether an innovator or creator is exhibiting sociopathic behavior or not. This aspect of drug addiction is inherently a matter of social values and ethics.
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Legal and Regulatory Approaches to Minimizing Drug Abuse
Medical Treatment and Research Efforts
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abstinence abstinence syndrome action activity acute addiction liability agents agonistic alcohol Amer amphetamine analgesia analgesics anesthetics animals antagonized barbital barbiturates behavior benzodiazepines brain chlordiazepoxide chlorpromazine chronic administration Clin clinical codeine cortical cyclazocine decreased depression detection diazepam doses of morphine drug abuse drug addiction drugs of abuse effects of morphine ethanol evoked extraction FRASER and ISBELL GORODETZKY HAERTZEN heroin HIMMELSBACH increase inhibition intoxication JASINSKI levels levorphanol marihuana MARTIN mechanisms MENDELSON meperidine meprobamate metabolism methadone methods mg/kg mice monkey morphinelike mouse nalorphine naloxone naltrexone narcotic addicts narcotic analgesics narcotic antagonists neurons observed opiate patients pentazocine pentobarbital Pharmacol pharmacologic phine physical dependence potential precipitated abstinence procedure propiram Psychiat Psychopharmacologia Berl receptor reflex reported reserpine response screening sedative/hypnotics sensitivity signs of abstinence single doses spinal cord stimulation studies subjective effects suppress Ther tion tolerance and physical tolerance develops treatment urine Wikler withdrawal