Drug Discovery and Development: Technology in Transition

Front Cover
H. P. Rang, Daniel Vasella
Churchill Livingstone / Elsevier, 2006 - Medical - 346 pages
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This title is directed primarily toward health care professionals outside the United States. An ideal introduction to the pharmaceutical industry, this book describes the process of bringing a new drug to the marketplace. It explains why, although thousands of compounds show initial promise, only a small handful will be developed for human clinical trials and perhaps only one will become an approved drug. Describing the huge complexities involved, it shows how new molecular understanding and techniques can make the process more targeted and successful.

  • Includes the new molecular techniques of drug design and development.
  • Discusses current therapeutic needs.
  • Covers pharmacoepidemiology and pharmacoeconomics.
  • Edited by Humphrey Rang, who is also known throughout the world as a co-author of the enormously successful and authoritative textbook, Pharmacology, now in its fifth edition.
  • Foreword by Daniel Vasella, CEO, Novartis International.
  • Includes contributors from both the pharmaceutical industry and universities.

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Contents

INTRODUCTION AND BACKGROUND DRUG DISCOVERY
6
general principles
45
The nature of disease and the purpose of 5 Choosing the project
57
Copyright

15 other sections not shown

Common terms and phrases

activity allow analysis animals application approach approval assays assessment authorities basis binding biological cause cells changes Chapter chemical chemistry clinical clinical trials companies complex compounds cost countries currently defined described determine disease dose drug discovery early effects efficacy enzymes evaluation example expression factors Figure function gene genetic genome groups human identified important improve increase industry involved known lead less major marketing measure Medicinal Chemistry medicine methods models molecular molecules natural normally optimization organization particular patent performed pharmaceutical pharmacokinetic pharmacological Phase possible potential predict problems properties protein range recent receptor regulatory represents response safety scientific screening selected sequence silico specific stage structure studies successful targets therapeutic therapy tion tissues toxicity treatment types usually validity

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Bibliographic information

QR code for Drug Discovery and Development
TitleDrug Discovery and Development: Technology in Transition
EditorsH. P. Rang, Daniel Vasella
ContributorDaniel Vasella
Editionillustrated, reprint
PublisherChurchill Livingstone / Elsevier, 2006
Original fromthe University of Michigan
DigitizedNov 27, 2007
ISBN0443064202, 9780443064203
Length346 pages
Subjects › 

Medical / Pharmacy
  
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