Drug Discovery and Development: Technology in TransitionThis title is directed primarily toward health care professionals outside the United States. An ideal introduction to the pharmaceutical industry, this book describes the process of bringing a new drug to the marketplace. It explains why, although thousands of compounds show initial promise, only a small handful will be developed for human clinical trials and perhaps only one will become an approved drug. Describing the huge complexities involved, it shows how new molecular understanding and techniques can make the process more targeted and successful.
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Contents
INTRODUCTION AND BACKGROUND DRUG DISCOVERY | 6 |
general principles | 45 |
The nature of disease and the purpose of 5 Choosing the project | 57 |
Copyright | |
15 other sections not shown
Common terms and phrases
activity allow analysis animals application approach approval assays assessment authorities basis binding biological cause cells changes Chapter chemical chemistry clinical clinical trials companies complex compounds cost countries currently defined described determine disease dose drug discovery early effects efficacy enzymes evaluation example expression factors Figure function gene genetic genome groups human identified important improve increase industry involved known lead less major marketing measure Medicinal Chemistry medicine methods models molecular molecules natural normally optimization organization particular patent performed pharmaceutical pharmacokinetic pharmacological Phase possible potential predict problems properties protein range recent receptor regulatory represents response safety scientific screening selected sequence silico specific stage structure studies successful targets therapeutic therapy tion tissues toxicity treatment types usually validity