Drugs from the Sea
Karger Medical and Scientific Publishers, Jan 1, 2000 - Medical - 158 pages
The present book consists of three parts: discovery, development and production of drugs from marine organisms. Marine bacteria, fungi, microalgae, sponges and opisthobranch mollusks have attracted much attention as sources of potential drugs, which is described in the first part. A pain-killing drug developed from the venom of a cone shell is a recent highlight of marine natural product research; the interesting story of its discovery is provided. The second part features an anticancer drug with a novel mode of action which was originally isolated from a songe and a potential antiosteoporotic drug of a hexacoral origin. But the most serious problem for development of drugs from the sea remains supply. Two possible solutions, production by fermentation and by aquaculture, are described in the third part. Identification and culture of symbiotic bacteria which are responsible for the production of bioactive sponge metabolites are the main objectives for many researchers.
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Drug Discovery Current Status and Future Potential
Microalgae as a Drug Source
Search for Biologically Active Substances from Marine Sponges
Cytotoxic Substances from Opisthobranch Mollusks
From Marine Snail Venom to Analgesic Drug
KRN7000 as a New Type of Antitumor and Immunostimulatory Drug
Zoanthamines Antiosteoporotic Alkaloids
actinomycete agents alkaloids Antibiot anticancer antifungal antitumor activity aplyronine aquaculture arenastatin assay aurilide 24 bacteria bacterium bioactive biological activity bryostatin calcium channels Cancer CD1d cell line Chem Chem Soc chemical clinical trials compounds conotoxin MVIIA culture cyanobacteria cytotoxic depsipeptides diﬀerent dinoﬂagellates dolastatin drug Ecteinascidin 743 eﬀects eﬀorts Faulkner DJ Fenical ﬁg ﬁlaments ﬁrst fungi Fusetani g/kg g/ml halichondrin hare Dolabella auricularia homohalichondrin identiﬁed inhibited inhibitors isodolastatin isolated Jensen PR Kigoshi H Kobayashi Koezuka larvae macrolides marine bacterium marine fungus marine microorganisms marine natural products marine sponge metastasis mice microalgae microorganisms murine Nat Prod Neurex NKT cells norzoanthamine norzoanthamine hydrochloride novel Numata Ojika okadaic acid organisms peptides pharmaceutical polyketide potent cytotoxic screening sea hare sea hare Dolabella secondary metabolites Sediment Shimizu signiﬁcant signiﬁcantly species speciﬁc spleen cells sponge cells sponge metabolites stereostructure strains Streptomyces structure studies suﬃcient symbiotic Takahashi Tetrahedron Lett therapeutic tubulin tumor cells venom vitro vivo Yamada