Drugs from the Sea

Front Cover
Nobuhiro Fusetani
Karger Medical and Scientific Publishers, Jan 1, 2000 - Medical - 158 pages
The present book consists of three parts: discovery, development and production of drugs from marine organisms. Marine bacteria, fungi, microalgae, sponges and opisthobranch mollusks have attracted much attention as sources of potential drugs, which is described in the first part. A pain-killing drug developed from the venom of a cone shell is a recent highlight of marine natural product research; the interesting story of its discovery is provided. The second part features an anticancer drug with a novel mode of action which was originally isolated from a songe and a potential antiosteoporotic drug of a hexacoral origin. But the most serious problem for development of drugs from the sea remains supply. Two possible solutions, production by fermentation and by aquaculture, are described in the third part. Identification and culture of symbiotic bacteria which are responsible for the production of bioactive sponge metabolites are the main objectives for many researchers.
 

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Contents

Drug Discovery Current Status and Future Potential
6
Microalgae as a Drug Source
30
Search for Biologically Active Substances from Marine Sponges
46
Cytotoxic Substances from Opisthobranch Mollusks
59
From Marine Snail Venom to Analgesic Drug
74
KRN7000 as a New Type of Antitumor and Immunostimulatory Drug
86
Zoanthamines Antiosteoporotic Alkaloids
98
Sources of Bioactive Substances
107
Aquacultural Production of Bryostatin 1 and Ecteinascidin 743
120
Chemistry Biology Supply and Delivery
134
Author Index
154
Subject Index
155
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