Drugs from the Sea
Karger, Jan 1, 2000 - Medical - 158 pages
Marine organisms have attracted much attention as potential sources for drugs over recent years. This timely book covers the discovery, development and production of drugs from marine bacteria, fungi, microalgae, sponges and opisthobranch mollusks. A recent highlight of marine natural product research described here is the development of a painkilling drug from the venom of a sea snail. Detailed accounts are also given on a novel anticancer drug, which was first isolated from a sponge, and a potential antiosteoporotic drug of hexacoral origin. The main challenge for future new drugs from the sea remains supply, but with production by fermentation and aquaculture two promising solutions are presented. The paper dealing with the identification and culture of symbiotic bacteria responsible for the production of bioactive sponge metabolites will make valuable reading for many researchers. 'Drugs from the Sea' will be of special interest to marine ecologists, chemists, and pharmacologists involved in drug development.
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Microalgae as a Drug Source
Search for Biologically Active Substances from Marine Sponges
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agents alkaloids altohyrtins analogue Antibiot anticancer drug antifungal antitumor activity aplyronine aquaculture arenastatin ascidian assay aurilide 24 bacteria bacterium bioactive biological activity biomass bryostatin calcium channels callystatin cancer cell line Chem Chem Soc chemical clinical trials co-conotoxin MVIIA colonies compounds cone snail culture cyanobacteria cytotoxic depsipeptides dinoflagellates dolastatin doliculide 20 extract Faulkner DJ Fenical fungi Fusetani halichondrin homohalichondrin inhibited inhibitors isodolastatin H isolated Jensen PR Kigoshi H Kobayashi Koezuka larvae macrolides marine bacterium marine fungus marine microbial marine microorganisms marine natural products marine sponge metastasis mice microalgae microorganisms Motoki murine Nat Prod Neurex NKT cells norzoanthamine norzoanthamine hydrochloride novel Numata Ojika okadaic acid organisms Ovariectomized peptide pharmaceutical polyketide potent antitumor potent cytotoxic screening sea hare secondary metabolites Sediment Shimizu species spleen cells sponge cells sponge metabolites stereostructure strains structure studies symbiont symbiotic Takahashi Tetrahedron Lett therapeutic total synthesis tubulin tumor cells ug/kg ug/ml venom vitro vivo Yamada