Dynamic-Clamp: From Principles to Applications

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Alain Destexhe, Thierry Bal
Springer Science & Business Media, Mar 11, 2009 - Medical - 429 pages
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Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called "conductance injection") allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer.

The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic-Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons.

This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.

About the Editors:

Dr. Alain Destexhe and Dr.Thierry Bal are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the research unit (Unité de Neurosciences Intégratives et Computationnelles, UNIC). Gif-sur-Yvette is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Dr. Bal and Dr. Destexhe. Each editor holds Ph.D.s in biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.

 

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Contents

an Introduction to Dynamic Clamp Principles and its Applications
1
Dendritic Dynamic Clamp A Tool to Study Single Neuron Computation
31
Synaptic Conductances and Spike Generation in Cortical Cells
48
Simulating In Vivo Background Activity in a Slice with the Dynamic Clamp
73
Impact of Background Synaptic Activity on Neuronal Response Properties Revealed by Stepwise Replication of In VivoLike Conditions In Vitro
88
Testing Methods for Synaptic Conductance Analysis Using Controlled Conductance Injection with Dynamic Clamp
115
Functional Roles of Shunting Inhibition and IBK in Rat and Cat Cortex
141
Functions of the Persistent Na+ Current in Cortical Neurons Revealed by Dynamic Clamp
165
Reactive Clamp and Modeling Studies
236
DynamicClampConstructed Hybrid Circuits for the Study of Synchronization Phenomena in Networks of Bursting Neurons
261
Using the Dynamic Clamp to Explore the Relationship Between Intrinsic Activity and Network Dynamics
274
DynamicClamp Applications Using RealTime Neuron
287
Using the Dynamic Clamp to Dissect the Properties and Mechanisms of Intrinsic Thalamic Oscillations
321
Dynamic Clamp with HighResistance Electrodes Using Active Electrode Compensation In Vitro and In Vivo
346
Key Factors for Improving DynamicClamp Performance
383
Insights from Dynamic Action Potential Clamp Experiments
399

Using Hard RealTime Dynamic Clamp to Study Cellular and Network Mechanisms of Synchronization in the Hippocampal Formation
198
Unraveling the Dynamics of Deep Cerebellar Nucleus Neurons with the Application of Artificial Conductances
217

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About the author (2009)

Dr. Alain Destexhe and Dr.Thierry Bal, are Research Directors at the Centre National de la Recherche Scientifique (CNRS), a governmental research institution in France. Their laboratories are located in the CNRS campus of Gif-sur-Yvette in the research unit (Unité de Neurosciences Intégratives et Computationnelles, UNIC). Gif-sur-Yvette is solely devoted to research and provides an ideal environment for close interaction between theory and experiments, as exemplified by the numerous publications on dynamic-clamp experiments co-authored by Bal and Destexhe. Each editor holds Ph.D.s in both biophysics and neurobiology, respectively. Dr. Destexhe is also Chief Editor of the Journal of Computational Neuroscience.

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