Early Life Origins of Health and Disease

Front Cover
E. Marelyn Wintour-Coghlan, Julie Owens
Springer Science & Business Media, Feb 26, 2007 - Medical - 228 pages

Early Life Origins of Health and Disease is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone. There is good evidence that stress and more subtle dietary deficiencies, as well as placental malfunction, may increase the risk that the offspring will develop these problems in later life. Finally, new and emerging evidence for other areas of human health and disease such a motor control and mental health is critically reviewed for the first time. The book is a ‘must’ for all scientists interested in researching these areas, as there is a critical evaluation of the methodology used and suggestions for the ‘optimal’ way in which to investigate these phenomena.

 

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Contents

DEVELOPMENTAL ORIGINS OF CARDIOVASCULAR DISEASE
8
Variation with Sex
15
Maternal Diabetes and Fetal Macrosomia
22
WHAT CAN THEY TELL US ABOUT
29
Are Findings in Twins Generalisable?
35
PRENATAL PROGRAMMING OF HUMAN MOTOR FUNCTION
41
The Case for Neurophysiological Assessment Induced Cortical Plasticity as Therapy
51
ADAPTIVE RESPONSES OF EARLY EMBRYOS TO THEIR
58
Conclusions
127
Influence of Maternal Health on Fetal Renal Development
138
PROGRAMMING OF OBESITY EXPERIMENT AL EVIDENCE
145
The Couch Potato Syndr ome I150
151
PERINATAL PROGRAMMING OF ADULT METABOLIC
157
How Could the Perinatal Environment Influence Adult
159
Mechanistic Basis for Programming of Metabolic Homeostasis Evidence fr
171
PROGRAMMING EFFECTS OF EXCESS GLUCOCORTICOID
177

Mechanisms for Altered Phenotype
64
MODIFICATION OF EPIGENETIC STATE THROUGH
70
The Influence of Diet on DNA Methylation Levels
72
CRITICAL EXPERINIENTS TO DETERMINE IF EARLY
79
MANIPULATION OF THE MATERNAL DIET IN
87
Conclusions
98
Models of Arterial Pressure Programming
104
Conclusions
114
DEVELOPMENTAL PROGRAMMING OF CARDIOVASCULAR
121
Conclusion
184
Immune System
190
VITAMIN D IN PREGNANCY AND OFFSPRING HEALTH
195
THE FETAL ORIGINS OF ADULT MENTAL ILLNESS
204
Other Neuropathological Features
210
HYPOXIA FETAL GROWTH AND DEVELOPMENTAL
219
INDEX
225
Copyright

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About the author (2007)

Professor Owens is an internationally recognized researcher in developmental physiology and endocrinology and in the early life programming of adult health and disease, diabetes and obesity in particular. She has published over 140 research papers, reviews and book chapters. She has been invited to present numerous plenary lectures or symposia at international or national conferences, and to convene and chair international symposia and plenary sessions at the First, Second and Third World Congresses for the Developmental Origins of Adult Health and Disease (previously Fetal Origins of Adult Disease). She was awarded the McCance Medal for outstanding contributions to perinatal research.

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