The Effects of Exercise Training and Acute Exacerbations on Muscle Function in Patients with Chronic Obstructive Pulmonary Disease
This is a Ph.D. dissertation. Chronic obstructive pulmonary disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases. Clinically, it is characterized by complaints of cough, sputum production, and/or dyspnoea, and diagnosed by a significantly reduced Tiffeneau index. It was the fourth leading cause of death in the United States in 1996, exceeded only by heart attacks, cancers and stroke. Hence, COPD is a major global health problem and its burden on society is growing rapidly. For these reasons, COPD was chosen as a study population in the present project.
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Muscle force during an acute exacerbation in hospitalised
Expression of inflammatory and anabolic markers in vastus
Acute anabolic and inflammatory responses to peak
Exercise training during rehabilitation of patients with
Resistance versus endurance training in patients with
Baseline levels of systemic anabolic and inflammatory
6MWD acute COPD exacerbation acute exacerbation Am.J.Respir Am.J.RespirCrit anabolic and inflammatory anabolic markers baseline circulating levels body mass index chronic heart failure chronic obstructive pulmonary clinically stable COPD CRDQ Crit CXCL8 cycling cytokines Decramer dyspnoea E. F. Wouters effects of exercise endurance training Eur:Respir.J European Respiratory Journal European Respiratory Society exacerbation of COPD exercise training expressed FEV1 Gosselink health-related quality healthy control subjects hospital hospitalised patients IGF-I improvements inflammatory markers insulin-like growth factor interleukin Jobin LeBlanc Maltais mRNA muscle strength obstructive pulmonary disease outpatient patients with chronic patients with COPD peak external peripheral muscle force peripheral muscle weakness pg/ml physical activity present study protein pulmonary rehabilitation quadriceps peak torque reference values rehabilitation programme resistance training respiratory rehabilitation significant significantly skeletal muscle skeletal muscle force skeletal muscle weakness Spruit stable COPD patients symptom-limited Thorax TNF-a TNF-o training in patients Troosters tumor necrosis factor vastus lateralis muscle weakness in patients