Embryo Implantation: Molecular, Cellular and Clinical Aspects

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Daniel D. Carson
Springer Science & Business Media, Sep 24, 1999 - Medical - 308 pages
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Embryoimplantationisaremarkableandcomplexprocess. Approachesde­ velopedfromthefieldsofcellanddevelopmentalbiology,immunology, andmolecularbiologyhavegreatlyenhancedourabilitytostudythe sharedaswellasuniquefeaturesofembryo-uterineinteractions. Impres­ siveandcriticalgroundworkhasbeenlaidbyalargeanddedicatedarray ofendocrinologists,reproductivebiologists,andanatomists. Thesestudies havesetthestagetoutilizesensitiveandsophisticatedtechniquestode­ tectandmodulateproteinandgeneexpression. Justasthesymbiosisofmother andfetusiscriticalforthemaintenanceofpregnancy,soisthesynergyamong investigatorsfrommanydisciplines,bothinbasicandclinicalarenas,keyto unravelingthemysteriesofimplantationandplacentation. Alargegroupof contributorsinthisfieldhadtheopportunitytomeetanddiscussthestateof thisartwiththesupportofSeronoSymposiaUSA,Inc. Whileitisneverpos­ sibletobringtogethereveryonewhohasplayedanimportantrole,itwas, nonetheless,bothexcitingandgratifyingtohavesomanycolleaguestogether forthisevent. Inthechaptersthatfollow,thehighlightsofthismeetingarepresented assummarizedbytheindividualpresentersofsevendifferentsessions. The topichasbeenconsideredfromthebroadsocialandethicalimplications ofmoderninvitrofertilizationandassistedreproductivetechnologiesto detailedmolecularcontrolsovereventsthatoccurduringembryonicdevel­ opment,uterinepreparationforimplantation,andplacentalorganogenesis. Thesechaptersdemonstratethesignificantandrapidprogressbeingmade inthisfieldofbiologyandmedicine. Atthesametime,theyshowthat muchmoreneedstobedonetounderstandandfullyappreciatethispro­ cess. Lessonslearnedfromthiseffortcanbeexpectedtocontinuetopro­ videinsightsintoother,relatedfields. Ofthemanycontributorstoour understandingoftheprocessofimplantation,nonehavehadalargerim­ pactthanourcolleague,AllenEnders. Dr. Endershasplayedaparamount roleindevelopingthebasicunderstandingofthecellbiologicalprocesses vii VIII Preface underlyingimplantationandplacentationinmanyspecies,includinghu­ mans. Hecontinuestocontributeandguidethoughtintheseareas. The participantsofthissymposiumrecognizedDr. Enders''impressivecontribu­ tionsbyholdingthiseventinhishonor. DANIELD. CARSON * Contents Preface vii Contributors xiii PartI. Development and Future ofHuman In Vitro Fertilization and Embryo Implantation I. ImplantationintheHumanasViewedbyCanonLaw, CivilLaw,andNaturalReason 3 HOWARDW. JONES, JR. , RICHARDA. MCCORMICK, AND SUSAN L. CROCKIN 2. TheImpactofMaternalAgeandOvarianAge onImplantationEfficiency. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 STEVEN SPANDORFER AND ZEV ROSENWAKS Part II. CellularAspects ofImplantation 3. VascularInvasionDuringImplantationandPlacentation 23 ALLEN C. ENDERS AND THOMASN. BLANKENSHIP 4. OxygenRegulatesHumanCytotrophoblastProliferation, Differentiation,andInvasion:Implicationsfor EndovascularInvasioninNormalPregnancy andPreeclampsia 39 OLGA GENBACEV,YAN ZHOU, MICHAEL T. McMASTER, JOHNW. LUDLOW, CAROLINEH. DAMSKY, AND SUSAN1. FISHER 5. Embryo-MaternalInteractionsafterDiapause inaMarsupial 54 MARILYNB. RENFREE AND GEOFFREY SHAW IX x Contents 6. CellularInteractionsandtheCysteineProteinases intheProcessofMouseImplantation 67 BRUCE BABIARZ, SUZANNE AFONSO, ANDLINDA ROMAGNANO Part III. HormonalRegulation 7. NovelSteroid-RegulatedMarkersofImplantation 83 INDRANIC. BAGCHI 8. MolecularSignalinginImplantation 92 SANJOYK. DAS, BIBHASHC. PARIA, AND SUDHANSU K. DEY 9. IdentificationofProgesterone-RegulatedGenes intheUterus 107 CINDEER. FUNK, BERTW. O''MALLEY, AND FRANCESCO1. DEMAYO PartIV. MolecularMarkersofReceptivity 10. MucinsProvideaBarriertoEmbryoImplantation 123 MARYM. DESOUZA, GULNARA. SURVEYOR, XINHUI ZHOU, JoANNE JULIAN, ANDDANIELD. CARSON II. PotentialInvolvementofTrophinin,Bystin, andTastininEmbryoImplantation 132 MICHIKON. FUKUDA, DAITA NADANO,NAO SUZUKJ, AND JUN NAKAYAMA 12. OsteopontininHumanEndometrium: ARoleinEndometrialReceptivityand EmbryoImplantation? 141 CHRISTOS COUTIFARJS,AKINYINKA OMIGBODUN, PIOTR ZIOLKIEWICZ, AND JOHN HOYER PartV. TrophoblastFactors 13. TheRabbitasaModelforImplantation: InVivoandInVitroStudies 151 LORENH. HOFFMAN,D. RACHEL BREINAN, AND GARETHL. BLAEUER 14. RegulationofTrophoblastEndocrineFunction: ThePlacentaDoesItsOwnThingTranscriptionally. . . . . . . . . . . . . . . . . . . . . 161 JEROMEF. STRAUSSIII ANDLEE-CHUANKAo Contents XI 15. TranscriptionFactorsRegulatingtheDifferentiation oftheTrophoblastCellLineage 167 IANC. SCOTTANDJAMESC.
 

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Contents

Implantation in the Human as Viewed by Canon Law Civil Law and Natural Reason
3
The Impact of Maternal Age and Ovarian Age on Implantation Efficiency
12
Cellular Aspects of Implantation
21
Vascular Invasion During Implantation and Placentation
23
Oxygen Regulates Human Cytotrophoblast Proliferation Differentiation and Invasion Implications for Endovascular Invasion in Normal Pregnancy a...
39
EmbryoMaternal Interactions after Diapause in a Marsupial
54
Cellular Interactions and the Cysteine Proteinases in the Process of Mouse Implantation
67
Hormonal Regulation
81
Regulation of Trophoblast Endocrine Function The Placenta Does Its Own Thing Transcriptionally
161
Transcription Factors Regulating the Differentiation of the Trophoblast Cell Lineage
167
Primate Models and Human Studies
183
Hormonal Regulation of Endometrial Gene Expression in the Rhesus Monkey
185
EmbryoMaternal Dialogue in the Baboon Papio Anubis
202
Integrins and Uterine Receptivity
210
Keratinocyte Growth Factor in the Nonhuman Primate Endometrium Regulation and Action
223
Molecular Lesions in Infertility
242

Novel SteroidRegulated Markers of Implantation
83
Molecular Signaling in Implantation
92
Identification of ProgesteroneRegulated Genes in the Uterus
107
Molecular Markers of Receptivity
121
Mucins Provide a Barrier to Embryo Implantation
123
Potential Involvement of Trophinin Bystin and Tastin in Embryo Implantation
132
Osteopontin in Human Endometrium A Role in Endometrial Receptivity and Embryo Implantation?
141
Trophoblast Factors
149
The Rabbit as a Model for Implantation In Vivo and In Vitro Studies
151
Transcriptional Regulation of FetalMaternal Recognition
247
The Role of Abdominal B AbdB Hoxa Genes During Implantation
249
Possible Role of the Transcription Factor Oct34 in Control of Human Chorionic Gonadotropin Expression
261
Molecular Mechanisms Regulating Uterine Decidualization and Implantation CellCell and Cell Extracellular Matrix Interactions
271
Regulation of Hormone Receptor Gene Expression in Endometrium
287
Author Index
299
Subject Index
301
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