Encephalopathies: Webster's Facts and Phrases
Nonfiction Usage Patent UsageA Method for the Determination of Transmissible Spongiform Encephalopathies in Mammals: Patented by Geoffrey J. Barnard Russell on November 16, 2000. Abstract: This invention relates to a method for the determination of transmissible spongiform encephalopathies in mammals. More particularly, the invention concerns a novel method for the determination of the percentage of disease related prion protein in a sample by differential extraction using two solutions of a chaotropic agent. Moreover, the invention concerns the use of this percentage as a diagnostic marker for the transmissible spongiform encephalopathies (TSE).A Method of Detecting Transmissible Spongiform Encephalopathies: Patented by Gary Hsich, Kimbra Kenney, Clarence J. Gibbs and Michael G. Harrington on March 31, 1997. Abstract: This invention provides improved assays for the detection of transmissible spongiform encephalopathies (TSEs) in humans and non-human mammals. The methods involve detecting the presence or absence of 14-3-3 proteins in cerebrospinal fluid from the tested organism. Elevated levels of 14-3-3 are indicative of transmissible spongiform encephalopathies, in particular Creutzfeldt-Jacob disease in humans or mad cow disease in bovines.An Early Pre-Symptomatic Prion Diagnostic Blood Test for Encephalopathies: Patented by Annelies Resink, Nathalie Fuentes and Fabien Schweighoffer on December 1, 2003. Abstract: This invention relates to compositions and methods of detecting encophalopathies . in a subject. This invention also relates to genetic markers, nucleic acid preparations or libraries, and kits for use in the implementation of said detection methods. The compositions and methods of this invention can also be used for the diagnosis, characterization, progression monitoring, etc. of encophalopathies, including at early stages thereof, particularly Transmissible Spongiform Encephalopathies (TSE), including Bovine Spongiform Encephalopathies (BSE, Mad Cow disease).Antibodies Specific for Native Prp Sc: Patented by Stanley B. Prusiner, R. A. Williamson and Dennis R. Burton on September 13, 1996. Abstract: Prions are infectious pathogens that cause central nervous system spongiform encephalopathies in humans and animals. The current invention relates to methods for obtaining antibodies which specifically bind to naturally occurring scrapie isoform of prion protein (PrP Sc ) and to methods for using the antibodies in detecting PrP Sc in samples.Diagnostic Assay for Transmissible Spongiform Encephalopathies: Patented by Denis F. Hochstrasser, Jean-Charles Sanchez, Catherine G. Zimmermann and Elisabeth Guillaume on March 12, 2001. Abstract: Heart and brain fatty acid binding proteins (H-FABP, B-FABP) are markers for TSEs, especially CJD. The invention provides a diagnostic assay for either of these markers, preferably by enzyme immunoassay using a specific antibody thereto. Since H-FABP is also a marker for acute myocardial infarction (AMI), to distinguish CJD from AMI requires an assay specific to AMI, e.g. using troponin-1 or CK-MB as a marker, also to be carried out.Diagnostic Method for Transmissible Spongiform Encephalopathies: Patented by Denis F. Hochstrasser, Jean-Charles Sanchez and Elisabeth Guillaume on September 3, 2002. Abstract: Transmissible spongiform encephalopathy (TSE) is diagnosed in a subject by using mass spectrometry to observe a polypeptide in a sample of body fluid taken from the subject. The polypeptide is differentially contained in the body fluid of TSE-infected subjects and non-infected subjects, and has a molecular weight in the range of from 3500 to 30000.Early Diagnosis of Conformational Diseases: Patented by Claudio Soto and Gabriella Saborio on June 13, 2001. Abstract: A method for the diagnosis or detection of conformational diseases by assaying for a marker (the pathogenic conformer) of such diseases in a sample is described, which method comprises a cyclic amplification system to inc
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