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acid ACTINOMYCIN active against gram-positive aerobic amorphous white powder anthraquinone antibacterial antibiotic complex antibiotic isolated antibiotic produced antibiotic when cultured antibiotic when grown Antibiotics Japan antifungal ATCC Bacillus anthracis Bacillus subtilis based upon chemical Biol Candida albicans Chem chemical and spectroscopic chromatography common nutrient medium components COOH crystals from EtOH cultures of Streptomyces Decomp dose elaborates this antibiotic Escherichia coli Et2O etal EtOAc forms colourless crystals fungi German Patent glucose gram-negative bacteria gram-positive and gram-negative gram-positive bacteria ibid ig/ml inorganic salts insoluble isolated from cultures Japanese Patent LD50 in mice M.p. Indefinite M.p. Not given macrocyclic Me2CO medium at 27°C MeOH mg/kg intravenous minimum inhibitory concentration Mycobacterium phlei NRRL obtained from cultures penicillin produced by Streptomyces Pseudomonas aeruginosa range of gram-positive soluble in H2O spectroscopic analysis Staphylococcus aureus Streptococcus Streptomyces species streptothricin structure shown substance Tetrahedron Lett toxicity U.S. Patent vitro vivo yeast yields this antibiotic