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Risk Assessment and Risk Management in the European Community and in
Some Points of Interest for a Discussion
An Overview Curtis Travis
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activity allele alterations analysis animals apoptosis approach assay associated biomarkers BRCA1 breast cancer bronchial cancer risk assessment carcinogenesis carcinogens carcinoma cell cycle cell lung cell proliferation cellular chemicals chromosomal aberrations Chyczewski clonal expansion compounds concentration cytogenetic detection dioxin dose dose-response dysplasia effects endocrine disrupters Environ Health environmental enzymes epidemiological epithelium estimated estrogenic evaluation experimental exposure expression extrapolation foci follicular frequency function genetic genotoxic growth factor hepatic hepatocarcinogenesis hepatocellular hormone human hyperplasia incidence increased induced involved lesions levels liver lung cancer male malignant mechanisms metabolism methods methylation molecular molecules mutations neuroendocrine cells normal observed Oncogene ovarian cancer papillary parameters pathways PBTK model PCBs phenotype physiological pollutants polymorphism population preneoplastic protein pulmonary neuroendocrine rats receptor Research response risk assessment role serum specific squamous statistical studies susceptibility thyroid cancer tissue toxicity Toxicol Toxicology tumor suppressor genes xenobiotic xenoestrogens