Endogenous Sleep Substances and Sleep Regulation

Front Cover
Shojiro Inoué, Alexander A. Borbély
VSP, Dec 1, 1985 - Science - 266 pages
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This volume provides the first major overview, by eminent authorities on the subject, of recent developments in the field of endogenous substances and their regulation of sleep processes. The first two sections discuss general aspects of sleep regulation; including an historical overview, the restorative and adaptive functions of sleep, and evolutionary features. The third section contains contributions focussing on circadian rhythms in relation to humoral factors, hormones, neurotransmitters and metabolism. The sleep substances currently receiving most attention --- delta-sleep-inducing-peptide (DSIP), muramyl peptides, interleukin-1, sleep-promoting substance (SPS) and prostaglandin D2 --- are extensively discussed. Substances that may selectively modulate REM sleep are dealt with in the final section.
 

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Contents

Their Roles and Evolution S Inoué
3
Approaches to Sleep Regulation A A Borbély
13
Tissue Restitution and Sleep with Particular Reference
25
The Search for and Evaluation of SleepInducing Substances
41
Deprivation of Sleep and Rest in Vertebrates and Invertebrates
57
Unihemispheric Slow Wave Sleep in the Brain of Dolphins
67
Sleep as an Adaptive Process S Torii
77
Its Modulation
89
The Natural Occurrence and Some ExtraSleep Effects of DSIP
155
M W Graf A J Kastin and A J Fischman 15 5
167
Muramyl Peptides and Interleukin1 as Promotors of Slow Wave
182
Prostaglandin D2 Regulates Physiological Sleep
193
Effects of SleepPromoting Substances on the Rat Circadian
203
Effects of Prostaglandin D2 and SleepPromoting Substance
215
PSInducing Factors and the Noradrenergic System
227
an Endogenous REM Sleep
237

Effects of Continuous Infusions of TRH and GIF on Circadian
101
Y Takahashi S Usui S Ebihara and Y Honda I I
113
Neural Control of Circadian RestActivity Rhythm in Crickets
127
DSIPLike Material in Rat Brain Human Cerebrospinal Fluid
141

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