M. Widschwendter, S. Srivastava
IOS Press, 2007 - Medical - 137 pages
DNA methylation is an epigenetic process that occurs when a methyl group binds to one of DNA's four bases, cytosine. These changes are responsible for controlling the activity of genes by turning them off. This book contains ten articles that explore the details and challenges of cancer epigenetics.
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A.F. Gazdar Aberrant methylation adenocarcinoma adenomas agouti allele analysis assay associated behavior biomarker biopsy breast cancer cancer cells cancer patients carcinogenesis carcinoma CDKN2A cell lines cell lung cancer Clin Cancer Res clinical colon colorectal cancer CpG island CRC patients cyclin-dependent kinase diabetes diagnosis disease DNA methylation DNA methyltransferase early detection epigenetic alterations factor frequently methylated gene expression gene promoter genetic genome GSTP1 histologically histone human cancers IGF2 inhibitor J.D. Minna J.G. Herman lation lesions LG-ABN LOI of IGF2 Loss of imprinting lung adenocarcinoma lung cancer maternal metastasis methy methylation markers methylation status methyltransferase MGMT mice MLH1 molecular mutations non-small cell lung Oncogene phenotype plasma potential prognostic promoter hypermethylation promoter methylation prostate cancer protein RASSF1A RASSFIA methylation risk ROC curves S.B. Baylin samples screening sensitivity serum Sidransky smokers specific stage studies survival temozolomide therapy tion Toyooka tumor suppressor gene Widschwendter