Essentials of Glycobiology
Ajit Varki, Maarten J. Chrispeels
CSHL Press, 1999 - Science - 653 pages
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
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BIOSYNTHESIS METABOLISM AND FUNCTION 6 Monosaccharide Metabolism
Stype Lectins Galectins
Microbial Glycanbinding Proteins
Proteoglycans and Glycosaminoglycans
Other Classes of Golgiderived Glycans
Nuclear and Cytoplasmic Glycosylation
The OGlcNAc Modification
Structures Common to Different Types of Glycans
Degradation and Turnover of Glycans
Glycosylation in Model Organisms
Glycobiology of Plant Cells
PROTEINS THAT RECOGNIZE GLYCANS 22 Discovery and Classification of Animal Lectins
GLYCANS IN GENETIC DISORDERS AND DISEASE 31 Genetic Disorders of Glycosylation in Cultured Cells
Naturally Occurring Genetic Disorders of Glycosylation
Determining Glycan Function Using Genetically Modified Mice
Glycosylation Changes in Ontogeny and Cell Activation
Glycosylation Changes in Cancer
Glycobiology of Protozoal and Helminthic Parasites
Acquired Glycosylation Changes in Human Disease
METHODS AND APPLICATIONS 38 Structural Analysis and Sequencing of Glycans
Chemical and Enzymatic Synthesis of Glycans
Natural and Synthetic Inhibitors of Glycosylation
Glycobiology in Biotechnology and Medicine
Commonly Used Terms
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Acad acceptor activity adhesion affinity amino acid animal antibodies antigen bacteria binding Biochem Biol Chem biological biosynthesis blood group carbohydrate CDGS type cell surface cell types ceramide chains Chapter cloning complex core cytosolic defects deficiency degradation disease domain embryos expression Figure fucose fucosylated function galactose galectins GalNAc gangliosides gene genetic GlcNAc glucose glycan structures glycans Glycobiology glycoconjugates glycolipids glycoprotein glycosaminoglycans glycosidases glycosidic glycosphingolipids glycosylation glycosyltransferases Golgi GPI anchors heparan sulfate heparin homologous human hyaluronan inhibit inhibitors interactions involved lectins leukocyte ligands linkage lipid lymphocytes lysosomal enzymes mammalian mannose membrane mice modification moiety molecular molecules monosaccharide mouse mucins mutants N-glycans Natl O-GlcNAc O-linked oligosaccharide P-selectin pathway peptide phenotype phosphorylation plant lectins polylactosamine polypeptide polysaccharides precursor Proc proteins proteoglycans reaction receptor recognition residues role selectin sequence sialic acid sialidase sialoadhesin sialyl Siglecs specific studies substrate synthesis tein terminal tion tissues transferase transgenic tumor Varki vertebrate vitro
Page 207 - ... methods of tunable lasers as shown by Patel and his collaborators (67) promise to give infrared spectra of radicals and ions about which up to now very little is known. For example the vibrational frequencies in the ground state of CH2 are unknown at present. These few remarks may suffice to indicate that a great deal remains to be done in the study of the geometric and electronic structure of radicals and molecular ions. ACKNOWLEDGEMENT The work described in this lecture could not have been...
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