Essentials of Glycobiology

Front Cover
Ajit Varki, Maarten J. Chrispeels
CSHL Press, 1999 - Science - 653 pages
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

Ptype Lectins
345
Itype Lectins
363
Ctype Lectins
379
Selectins
391
Stype Lectins Galectins
417
Microbial Glycanbinding Proteins
429
Glycosaminoglycanbinding Proteins
441
Plant Lectins
455

Glycosphingolipids
115
Glycophospholipid Anchors
131
Proteoglycans and Glycosaminoglycans
145
Other Classes of Golgiderived Glycans
161
Nuclear and Cytoplasmic Glycosylation
171
The OGlcNAc Modification
183
Sialic Acids
195
Structures Common to Different Types of Glycans
211
Glycosyltransferases
253
Degradation and Turnover of Glycans
267
Glycosylation in Model Organisms
285
Glycobiology of Plant Cells
305
Bacterial Polysaccharides
321
PROTEINS THAT RECOGNIZE GLYCANS 22 Discovery and Classification of Animal Lectins
333
GLYCANS IN GENETIC DISORDERS AND DISEASE 31 Genetic Disorders of Glycosylation in Cultured Cells
469
Naturally Occurring Genetic Disorders of Glycosylation
479
Determining Glycan Function Using Genetically Modified Mice
499
Glycosylation Changes in Ontogeny and Cell Activation
515
Glycosylation Changes in Cancer
537
Glycobiology of Protozoal and Helminthic Parasites
551
Acquired Glycosylation Changes in Human Disease
565
METHODS AND APPLICATIONS 38 Structural Analysis and Sequencing of Glycans
581
Chemical and Enzymatic Synthesis of Glycans
599
Natural and Synthetic Inhibitors of Glycosylation
609
Glycobiology in Biotechnology and Medicine
625
Commonly Used Terms
635
Index
641
Copyright

Other editions - View all

Common terms and phrases

Popular passages

Page 207 - ... methods of tunable lasers as shown by Patel and his collaborators (67) promise to give infrared spectra of radicals and ions about which up to now very little is known. For example the vibrational frequencies in the ground state of CH2 are unknown at present. These few remarks may suffice to indicate that a great deal remains to be done in the study of the geometric and electronic structure of radicals and molecular ions. ACKNOWLEDGEMENT The work described in this lecture could not have been...
Page 448 - DM (1991) Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor.
Page 159 - Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility', J Cell Biol 136, 729-743.
Page 302 - The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein. PKD1 . J.
Page 629 - Relationship between sugar chain structure and biological activity of recombinant human erythropoietin produced in Chinese hamster ovary cells. Proc Natl Acad Sci USA 1989; 86:7819-7822.
Page 249 - Bleil, JD and Wassarman, PM (1988) Galactose at the non-reducing terminus of O-linked oligosaccharides of mouse egg zona pellucida glycoprotein ZP3 is essential for the glycoprotein's sperm receptor activity. Proc.
Page 492 - Anderson, DC, Springer, TA (1987) Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1 and p150,95 glycoproteins.
Page 449 - Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents.
Page 247 - Sasaki K., Kurata K., Funayama K., Nagata M., Watanabe E., Ohta S., Hanai N., and Nishi T. 1994. Expression cloning of a novel al,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes.

References to this book

Lectins
Nathan Sharon,H. Lis
Limited preview - 2007
All Book Search results »

Bibliographic information