Essentials of Glycobiology
Ajit Varki, Maarten J. Chrispeels
CSHL Press, 1999 - Science - 653 pages
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
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B1OSYNTHESLS METABOLLSM AND FUNCTLON
PROTELNS THAT RECOGN1ZE GLYCANS 22 Discovery and Classification of Animal Lectins
Stype Lectins Galectins
Naturally Occurring Genetic Disorders of Glycosylation
Determining Glycan Function Using Genetically Modified Mice
Glycosylation Changes in Ontogeny and Cell Activation
Glycosylation Changes in Cancer
Glycobiology of Protozoal and Helminthic Parasites
Acquired Glycosylation Changes in Human Disease
METHODS AND APPLLCATLONS 38 Structural Analysis and Sequencing of Glycans
Chemical and Enzymatic Synthesis of Glycans
Microbial Glycanbin ding Proteins
GLYCANS LN GENETLC D1SORDERS AND DLSEASE 31 Genetic Disorders of Glycosylation in Cultured Cells
Natural and Synthetic 1nhibitors of Glycosylation
Glycobiology in Biotcchnology and Medicine
Commonly Used Terms
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activity addition adhesion amino analysis anchors animal antibodies antigen appears approach associated attached bacteria binding Biochem Biol biological biosynthesis blood group carbohydrate causes cell surface cells changes Chapter characterization Chem cloning common complex contain core cytoplasmic defects deficiency degradation determinants direct disease domain effects enzymes example exist expression F1GURE factor Figure formation function gene genetic GlcNAc glucose glycans Glycobiology glycoconjugates glycolipids glycoproteins glycosylation glycosyltransferases Golgi heparan human identified important indicate interactions involved known lectins levels ligands linkage lysosomal major mammalian mannose membrane mice modification molecular molecules monosaccharide mouse mutants N-glycans nature normal occur oligosaccharide organisms P-selectin pathway patients plant precursor present production proteins proteoglycans reaction receptor recognition recognized regulation relatively residues response role selectin sequence shown sialic acid sialyl signal specific structure studies sugar suggested sulfate synthesis Table termed terminal tion tissues transferase transport various
Page 193 - ... methods of tunable lasers as shown by Patel and his collaborators (67) promise to give infrared spectra of radicals and ions about which up to now very little is known. For example the vibrational frequencies in the ground state of CH2 are unknown at present. These few remarks may suffice to indicate that a great deal remains to be done in the study of the geometric and electronic structure of radicals and molecular ions. ACKNOWLEDGEMENT The work described in this lecture could not have been...
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