Essentials of Glycobiology

Front Cover
Ajit Varki, Maarten J. Chrispeels
CSHL Press, 1999 - Science - 653 pages
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. They participate in activities as diverse as protein folding, leukocyte physiology, and microbial pathogenesis. Genetic defects in their assembly are at the root of a growing list of human diseases. Essentials of Glycobiology describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
 

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Contents

GENERAL PR1NC1PLES
1
B1OSYNTHESLS METABOLLSM AND FUNCTLON
69
PROTELNS THAT RECOGN1ZE GLYCANS 22 Discovery and Classification of Animal Lectins
333
Ptype Lectins
345
1type Lectins
363
Ctype Lectins
379
Selecting
391
Stype Lectins Galectins
417
Naturally Occurring Genetic Disorders of Glycosylation
479
Determining Glycan Function Using Genetically Modified Mice
499
Glycosylation Changes in Ontogeny and Cell Activation
515
Glycosylation Changes in Cancer
537
Glycobiology of Protozoal and Helminthic Parasites
551
Acquired Glycosylation Changes in Human Disease
565
METHODS AND APPLLCATLONS 38 Structural Analysis and Sequencing of Glycans
581
Chemical and Enzymatic Synthesis of Glycans
599

Microbial Glycanbin ding Proteins
429
Glycosaminoglycanbinding Proteins
441
Plant Lectins
455
GLYCANS LN GENETLC D1SORDERS AND DLSEASE 31 Genetic Disorders of Glycosylation in Cultured Cells
469
Natural and Synthetic 1nhibitors of Glycosylation
609
Glycobiology in Biotcchnology and Medicine
625
Commonly Used Terms
635
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