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ToxicokineticsA Role in Drug
The Role of Drug Disposition in the Interpretation
Selective Disposition Studies in Drug
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52 weeks absorption ACHC acid administration alcohol glucuronide American aminoglycoside amphetamine animals auranofin bioavailability blood levels body clearance captopril cefonicid chemical Clinical Pharmacokinetics Clinical Pharmacology compound correlation covalent binding cyclacillin decrease dialysis diet differences dinitrotoluenes dogs and monkeys dosage levels drug disposition studies drug exposure drug metabolism enzyme excretion Figure fluoxetine gastrointestinal gentamicin glomerular filtration glomerular filtration rate glucuronide hepatic humans ingested intestine intravenous kidney kinetics liver male rats Medical metabolites mg/kg mg/kg/day monitoring multiple dosing N-Acetylprocainamide NAPA nephrotoxicity organs overdose patients perfusion Pharmaceutical Sciences pharmacokinetic Pharmacol Pharmacology Phase phenytoin plasma plasma concentrations plasma levels preclinical predict procainamide ratio relationship renal clearance Reprinted with permission Schentag serum concentrations serum creatinine single dose species steady-state Table theophylline therapeutic tissue accumulation tobramycin toxic effects toxicokinetic studies toxicokinetics toxicologic response toxicology toxicology studies ug/ml urinary urine volume of distribution Yacobi