Extracellular Matrix: Chemistry: Biology, and Pathobiology with Emphasis on the Liver

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Mark A. Zern, Lola M. Reid
CRC Press, Apr 1, 1993 - Science - 624 pages
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Describing state-of-the-art research techniques for clinicians and introducing important clinical perspectives for basic scientists, this reference examines some significant areas of investigation into the biology of the extracellular matrix and its implications in human pathophysiology.;Focusing on the liver and providing a broad survey of the latest information available, Extracellular Matrix: discusses a wide range of models and organ systems; presents pathophysiological studies emphasizing hepatic disease, particularly the development of fibrosis and cirrhosis; furnishes structure and function analyses of the major extracellular matric components, including collagens, laminin, fibronectin, and proteoglycans; delineates the mechanisms leading to increased depositions of the matrix proteins during hepatic fibrogenesis; details new therapeutic approaches to liver disease; and more.;With authoritative contributions from more than 40 leading international experts representing five countries, Extracellular Matrix should be a useful reference for all scientists interested in matrix biology, chemistry, or pathobiology, especially gastroenterologists, hepatologists, pathologists, and graduate and medical school students in these disciplines.
 

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Contents

Fibronectin
19
Structure and Function of Laminin and Gene Regulation
49
Adhesion Molecules in Embryogenesis and Histogenesis
67
Regulation of Collagen Gene Expression
91
Their Biosynthesis Molecular Structure
121
Structure Assembly
149
PropeptideMediated Regulation of Procollagen Synthesis
187
Morphology Localization and Origin of the Hepatic
255
Novel Approaches
383
Extracellular Matrix and the Development of Tissue
403
Inhibition of SmoothMuscle Cell Proliferation
429
Matrix Regulation of Gap Junctions and of Excitability in Cells
449
Extracellular MatrixResident Growth Factors and Enzymes
463
Cell Adhesion Mediated by Matrix Components
491
The Liver as a Stem Cell and Lineage System
507
Pathogenesis of Hepatic Fibrosis
541

Peptide Hormone and Cytokine Regulation of Matrix Synthesis
331
Glucocorticoid Regulation of Procollagen Synthesis
351
Prostaglandins Effects on the Extracellular Matrix
369
Extracellular Matrix and Metastasis
559
Index
581
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