Facing the Reality of Drug-Resistant Tuberculosis in India: Challenges and Potential Solutions: Summary of a Joint Workshop by the Institute of Medicine, the Indian National Science Academy, and the Indian Council of Medical Research

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An estimated 8.8 million people fell ill with tuberculosis (TB) in 2010 and 1.4 million died from the disease. Although antibiotics to treat TB were developed in the 1950s and are effective against a majority of TB cases, resistance to these antibiotics has emerged over the years, resulting in the growing spread of multidrug-resistant (MDR) TB. Due to challenges in timely and accurate diagnosis of drug-resistant TB, length and tolerability of treatment regimens, and expense of second-line anti-TB drugs, effectively controlling the disease requires complex public health interventions.

The IOM Forum on Drug Discovery, Development, and Translation held three international workshops to gather information from local experts around the world on the threat of drug resistant TB and how the challenges it presents can be met. Workshops were held in South Africa and Russia in 2010. The third workshop was held April 18-19, 2011, in New Delhi, India, in collaboration with the Indian National Science Academy and the Indian Council of Medical Research. The aim of the workshop was to highlight key challenges to controlling the spread of drug-resistant strains of TB in India and to discuss strategies for advancing and integrating local and international efforts to prevent and treat drug-resistant TB. This document summarizes the workshop.

 

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Contents

1 Introduction
1
2 DrugResistant TB in India
17
3 The Global Burden of DrugResistant TB
37
4 Preventing Transmission of DrugResistant TB
49
5 Detecting Drug Resistance and Strengthening Laboratory Capacity
59
6 Addressing TB and DrugResistant TB in Vulnerable Populations
71
7 Combating DrugResistant TB Through PublicPrivate Collaboration and Innovative Approaches
89
8 Confronting Challenges to the Supply Chain for SecondLine Drugs
99
9 Creating a Blueprint for Action
113
References
121
Workshop Agenda
129
Summary of a Joint Meeting of the National Institute of Allergy and Infectious Diseases National Institutes of Health and Indian Biomedical Research...
141
Participant Biographies
145
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