Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life

Front Cover
Springer Science & Business Media, May 11, 2008 - Medical - 79 pages
0 Reviews

In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.

 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

I
1
III
3
V
5
VII
7
IX
9
XI
10
XV
12
XVII
14
XLVII
35
XLIX
36
LI
37
LIII
39
LVI
40
LVII
41
LIX
43
LXI
46

XIX
15
XXI
16
XXV
17
XXXI
18
XXXIII
20
XXXV
21
XXXVII
24
XXXVIII
25
XL
27
XLII
28
XLIII
32
LXIII
47
LXV
48
LXVII
49
LXIX
53
LXXIII
54
LXXIV
55
LXXVI
56
LXXIX
58
LXXX
79
Copyright

Other editions - View all

Common terms and phrases

Popular passages

Page i - It is a fundamental condition that submitted manuscripts have not been and will not simultaneously be submitted or published elsewhere. With the acceptance of a manuscript for publication, the publisher acquires full and exclusive copyright for all languages and countries.
Page 74 - Sorokin, L., Sonnenberg, A., Aumailley, M., Timpl, R., and Ekblom, P. (1990). Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules.

Bibliographic information