Fatigue: Neural and Muscular Mechanisms

Front Cover
Springer Science & Business Media, Nov 30, 1995 - Science - 542 pages
This volume describes the current state of our knowledge on the neurobiology of muscle fatigue, with consideration also given to selected integrative cardiorespiratory mechanisms. Our charge to the authors of the various chapters was twofold: to provide a systematic review of the topic that could serve as a balanced reference text for practicing health-care professionals, teaching faculty, and pre-and postdoctoral trainees in the biomedi cal sciences; and to stimulate further experimental and theoretical work on neurobiology. Key issues are addressed in nine interrelated areas: fatigue of single muscle fibers, fatigue at the neuromuscular junction, fatigue of single motor units, metabolic fatigue studied with nuclear magnetic resonance, fatigue of the segmental motor system, fatigue involving suprasegmental mechanisms, the task dependency of fatigue mechanisms, integrative (largely cardiorespiratory) systems issues, and fatigue of adapted systems (due to aging, under-and overuse, and pathophysiology). The product is a volume that provides compre of processes that operate from the forebrain to the contractile proteins.
 

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Contents

MYOFIBRILLAR FATIGUE VERSUS FAILURE OF ACTIVATION
27
MECHANISMS OF EXCITATIONCONTRACTION COUPLING RELEVANT TO SKELETAL MUSCLE FATIGUE
43
THE ROLE OF INTRACELLULAR ACIDOSIS IN MUSCLE FATIGUE
55
ROLE OF INTERSTITIAL POTASSIUM
67
Fatigue at the Neuromuscular Junction
79
FATIGUE AT THE NEUROMUSCULAR JUNCTION Branch Point vs Presynaptic vs Postsynaptic Mechanisms
81
THE ROLE OF THE SARCOLEMMA ACTION POTENTIAL IN FATIGUE
99
SINGLE FIBER ELECTROMYOGRAPHY IN STUDIES OF NEUROMUSCULAR FUNCTION
107
SINGLETRIAL READINESS POTENTIALS AND FATIGUE
293
THE SENSES OF EFFORT AND FORCE DURING FATIGUING CONTRACTIONS
303
TRYPTOPHAN 5HYDROXYTRYPTAMINE AND A POSSIBLE EXPLANATION FOR CENTRAL FATIGUE
313
Task Dependency of Fatigue Mechanisms
319
THE SIGNIFICANCE OF MOTOR UNIT VARIABILITY IN SUSTAINING MECHANICAL OUTPUT OF MUSCLE
321
INTRAMUSCULAR PRESSURES FOR MONITORING DIFFERENT TASKS AND MUSCLE CONDITIONS
337
TASKDEPENDENT NATURE OF FATIGUE IN SINGLE MOTOR UNITS
349
TASKDEPENDENT FACTORS IN FATIGUE OF HUMAN VOLUNTARY CONTRACTIONS
359

Fatigue of Single Motor Units
119
INTRINSIC PROPERTIES OF MOTONEURONS Implications for Muscle Fatigue
121
NEUROMUSCULAR FREQUENCYCODING AND FATIGUE
133
HUMAN MOTOR UNITS STUDIED BY SPIKETRIGGERED AVERAGING AND INTRANEURAL MOTOR AXON STIMULATION
145
HUMAN MOTOR UNITS STUDIED BY INTRAMUSCULAR MICROSTIMULATION
159
Fatigue Studied with NMR Techniques
171
BIOENERGETICS AND MUSCLE CELL TYPES
173
METABOLIC CORRELATES OF FATIGUE FROM DIFFERENT TYPES OF EXERCISE IN MAN
183
MECHANISMS OF HUMAN MUSCLE FATIGUE Quantitating the Contribution of Metabolic Factors and Activation Impairment
193
EMERGING OPPORTUNITIES WITH NMR
209
VARIABLEFREQUENCY STIMULATION PATTERNS FOR THE OPTIMIZATION OF FORCE DURING MUSCLE FATIGUE Muscle Wisdom an...
225
OVERVIEW POTENTIAL ROLE OF SEGMENTAL MOTOR CIRCUITRY IN MUSCLE FATIGUE
239
THE FUSIMOTOR SYSTEM Its Role in Fatigue
257
ROLE OF MUSCLE AFFERENTS IN THE INHIBITION OF MOTONEURONS DURING FATIGUE
269
The Case for Central Fatigue
277
CENTRAL FATIGUE Critical Issues Quantification and Practical Implications
279
Integrative Systems Issues
379
FATIGUE AND THE DESIGN OF THE RESPIRATORY SYSTEM
381
AN INTEGRATIVE VIEW OF LIMITATIONS TO MUSCULAR PERFORMANCE
391
RESPIRATORY MUSCLE FATIGUE
399
FATIGUE OF JAW MUSCLES AND SPEECH MECHANISMS
413
Fatigue of Adapted Systems Overuse Underuse and Pathophysiology
425
FATIGUE IN ADAPTED SYSTEMS Overuse and Underuse Paradigms
427
ASSOCIATIONS BETWEEN MUSCLE SORENESS DAMAGE AND FATIGUE
455
MUSCLE FATIGUE IN OLD ANIMALS Unique Aspects of Fatigue in Elderly Humans J A Faulkner and S V Brooks
469
HISTORICAL PERSPECTIVE A FRAMEWORK FOR INTERPRETING PATHOBIOLOGICAL IDEAS ON HUMAN MUSCLE FATIGUE
479
FATIGUE BROUGHT ON BY MALFUNCTION OF THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS
493
NEUROBIOLOGY OF MUSCLE FATIGUE Advances and Issues
513
CONTRIBUTORS
525
INDEX
531
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