Fetal Alcohol Abuse Syndrome
My initial purpose in writing this book was to offer readers an update of my book Fetal Alcohol Syndrome and Fetal Alcohol Effects (Plenum, 1984), which con tained a broad overview of the history (actually the absence of any history) ofthe awareness of alcohol's teratogenic potential; a review of alcohol's pharmacology, especially with respect to pregnancy; a survey of the physical and behavioral effects of prenatal alcohol exposure; and an overview of the mechanisms sus pected of being responsible for those effects. I have omitted most of the previously examined historical and pharmacologi cal information because not much of what was previously discussed needed revision. On the other hand, because much more has been learned about the consequences of prenatal alcohol exposure and its potential mechanisms of action, I have considerably expanded my discussion of these topics. In doing so, I have attempted to include as much new material as possible without (I hope) being overly pedantic and thereby losing the proverbial forest for the trees. No book is ever entirely neutral in the topics it discusses, the issues it raises, or in its conclusions. In sifting through hundreds and oftentimes thousands of articles, writers have to choose which facts to emphasize and which to ignore. Every idea cannot be chronicled and every article cannot (and should not) be cited. In going about the business of picking and choosing, however, a writer has an obligation to present the arguments for and against a particular conclusion.
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Why Fetal Alcohol Abuse Syndrome?
Neurodevelopmental Abnormalities Structural and Sensory
Neurodevelopmental Abnormalities Behavioral and Cognitive
The American Paradox
Permissive and Provocative Factors in FAS
Conclusions and Implications
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Abel E. L. abnormalities acetaldehyde acid alcohol abuse alcohol abuse syndrome alcohol-related alcoholic women animals prenatally exposed anomalies ARBEs associated with FAS average behavior binge birth defects birth weight blood alcohol levels brain Caucasian cell cellular cerebellum Chapter child children with FAS children with FAS/ARBE Clarren Clinical and Experimental cognitive Coles corticosterone damage decreased diagnosis diet disorder drinkers drinking during pregnancy drinks a day dysmorphologist effects of prenatal Ernhart ethanol Experimental Research exposed to alcohol facial features factors FAS/ARBE fetal alcohol abuse fetal alcohol syndrome fetus free radical gestation glucose growth retardation heavy drinking incidence of FAS increased infants Jacobson Journal Majewski malformations maternal alcohol consumption maternal drinking metabolism Native American Neurotoxicology occur oxygen palpebral fissures Pediatrics philtrum placental population postnatal prenatal alcohol exposure preterm birth prevalence problems rats reported result smoking socioeconomic status Sokol Spohr spontaneous abortion statistically significant Streissguth teratogenic Teratology utero
Page 3 - For there exists a great chasm between those, on one side, who relate everything to a single central vision, one system less or more coherent or articulate, in terms of which they understand, think and feel— a single, universal, organizing principle in terms of which alone all that they are and say has significance...
Page 251 - Streissguth AP, Clarren SK, Jones KL. Natural history of the fetal alcohol syndrome: a 10-year follow-up of eleven patients.