Fetal Cells and Fetal DNA in Maternal Blood: New Developments for a New Millennium : 11th Fetal Cell Workshop, Basel, April 15, 2000

Front Cover
Sinuhe Hahn, Wolfgang Holzgreve
Karger Medical and Scientific Publishers, Jan 1, 2001 - Medical - 137 pages
Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation and transfusion medicine.
 

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Contents

An Important Tool for
16
An Overview of the Basel Experience
28
Using AMCA to Label the Fetal Cell Antigen in Fetal Erythroblasts
74
Fetal Cell Detection in Maternal Blood Using the Solid Phase Cytometer
82
Fetal CD34+ Cell Culture and Identification from Maternal Blood
91
Diagnostic and Clinical
97
Quantitative Analysis of Fetal DNA in Maternal Plasma in Preeclamptic
104
Circulating Trophoblast Cells in Maternal Peripheral Blood
111
Transcervical Sampling
120
Author Index
131
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