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IN VITRO STUDIES
STUDIES IN THE RABBIT
A Introduction and aims of the studies
STUDIES IN THE SHEEP
GENERAL DISCUSSION AND FUTURE PERSPECTIVES
allantoic AllF amniocentesis amnion amnion and chorion amniorrhexis amniotic cavity amniotic fluid angle of needle cellular clinical closure collagen plugs compared Contigen cytokines defect zone Deprest Dermabond Devlieger EECF evaluate experimental explants extra-embryonic extracellular matrix fetal membrane healing fetal membrane repair fetal surgery fetal wound fetoscopic access fetoscopy fetus fibrillar collagen fibrin fibroblast Figure flow rate fluid leakage Fortunato gelatinase gestational age gestational sacs Gratacos growth factor histology human amnion human fetal membranes iatrogenic IGFBP-1 increased incubation infiltration intrauterine matrix metalloproteinases Mean SD membrane defect monolayers myometrial myometrium needle diameter Obstet Gynecol oligohydramnios organ culture patients Pijnenborg polymorphonuclear positive controls post-procedural PPROM pregnancy premature rupture preterm procedure proliferation Protein pulmonary hypoplasia puncture Quintero rabbit Reprod samples sealing sheep significant significantly Singer and Clark spontaneous subclinical surgical suture TIMP activities tissue inhibitors trauma twin-twin transfusion syndrome uterine wall vitro vivo weeks wound healing zymography