Fetal and Neonatal Brain Injury: Mechanisms, Management and the Risks of Practice

Front Cover
David K. Stevenson, Philip Sunshine, William E. Benitz
Cambridge University Press, Feb 6, 2003 - Medical - 907 pages
Now in its third edition, this is a comprehensive survey of fetal and neonatal brain injury arising from hypoxia, ischemia or other causes. The volume spans a broad range of areas from epidemiology and pathogenesis, through to clinical manifestations and obstetric care, and then on to diagnosis, long-term outcomes, and medico-legal aspects. An important theme running throughout is to highlight scientific and clinical advances that have a role to play in minimising risk, improving clinical care and outcomes.
 

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Contents

Perinatal asphyxia an overview
3
Mechanisms of brain damage in animal models of hypoxiaischemia in newborns
30
Cellular and molecular biology of perinatal hypoxicischemic brain damage
58
Fetal responses to asphyxia
83
Congenital malformations of the brain
111
Prematurity and complications of labor and delivery
129
Intrauterine growth retardation restriction
145
Hemorrhagic lesions of the central nervous system
175
Placental pathology and the etiology of fetal and neonatal brain injury
519
Correlations of clinical laboratory imaging and placental findings as to the timing of asphyxial events
544
Specific Conditions Associated with Fetal and Neonatal Brain Injury
555
Hypoglycemia in the neonate
557
Hyperbilirubinemia and kernicterus
575
Polycythemia
582
Hydrops fetalis
590
Acidosisalkalosis
597

Pregnancy Labor and Delivery Complications Causing Brain Injury
189
Maternal diseases that affect fetal development
191
Antepartum evaluation of fetal wellbeing
212
Intrapartum evaluation of the fetus
226
Obstetrical conditions and practices that affect the fetus and newborn
244
Section II
256
Fetal and neonatal injury as a consequence of maternal substance abuse
274
Chorioamnionitis and its possible relation to subsequent cerebral palsy
303
Bacterial sepsis in the neonate
314
Neonatal bacterial meningitis
333
Neurologic sequelae of congenital perinatal infection
355
Perinatal human immunodeficiency virus infection
377
Inborn errors of metabolism with features of hypoxicischemic encephalopathy
392
Diagnosis of the Infant with Asphyxia
409
Clinical manifestations of hypoxicischemic encephalopathy
411
The use of the EEG in assessing acute and chronic brain damage in the newborn
425
Structural and functional imaging of hypoxicischemic injury HII in the fetal and neonatal brain
446
Nearinfrared spectroscopy and imaging
490
Meconium staining and the meconium aspiration syndrome
616
Persistent pulmonary hypertension of the newborn
640
Pediatric cardiac surgery relevance to fetal and neonatal brain injury
667
Management of the Depressed or Neurologically Dysfunctional Neonate
675
Neonatal resuscitation immediate management
677
Extended management
696
Neuroprotective mechanisms after hypoxicischemic injury
719
Neonatal seizures an expression of fetal or neonatal brain disorders
739
Improving performance reducing error and minimizing risk in the delivery room
789
Nutritional support of the asphyxiated infant
795
Assessing the Outcome of the Asphyxiated Infant
819
Assessment of preterm infants neurobehavioral functioning reliability validity normative data and prediction to age two
821
Longterm followup of term infants with perinatal asphyxia
833
Appropriateness of intensive care application
863
Medicolegal issues in perinatal brain injury
877
Index
891
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