Fetal Cells and Fetal DNA in Maternal Blood: New Developments for a New Millennium : 11th Fetal Cell Workshop, Basel, April 15, 2000
Sinuhe Hahn, Wolfgang Holzgreve
Karger, 2001 - Medical - 137 pages
Is noninvasive, risk-free prenatal diagnosis of fetal genetic characteristics still a fantasy, or will it soon become reality? The current status of both the leading European research groups as well as the NIH-funded NIFTY study are reported here, indicating that certain fetal genetic traits can now be examined efficiently in a noninvasive manner. Considerable focus is placed on new laser-mediated systems for the effective micro-manipulation of single fetal cells, as well as their analysis by single-cell PCR and the pitfalls to avoid when performing such analyses. Other issues addressed in depth include: novel enrichment techniques, optimal fetal cell recognition, fetal cell culture, as well as the exciting finding that fetal cell traffic is elevated in certain pregnancy-related disorders, most prominently in preeclampsia. This publication is of interest to researchers in the field, genetic counsellors, gynecologists and obstetricians, and researchers in microchimerism, transplantation and transfusion medicine.
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An Important Tool for
An Overview of the Basel Experience
Using AMCA to Label the Fetal Cell Antigen in Fetal Erythroblasts
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11th Fetal Cell abnormalities Acad Sci allele amniocentesis amplification analyzed aneuploid assay Basel Bianchi DW cancer patients CD34+ cells Cells and Fetal cells from maternal cells in maternal cFISH chorionic villus sampling chromosomal circulating DNA Clin density gradient detection of fetal developed DNA in maternal Down's syndrome enrichment of fetal erythrocytes Fetal Cell Workshop fetal cells fetal erythroblasts fetal NRBC fetal nucleated erythrocytes fetus fetuses FISH analysis flow cytometry fluorescence free fetal DNA gene Hahn Hum Genet hybridization inhibin isolated from maternal karyotyping labelled Lancet laser MACS marker maternal blood samples maternal cells maternal circulation maternal peripheral blood maternal plasma method monoclonal antibody mutation nucleated cells nucleated red blood Obstet Gynecol plasma plasma DNA polymerase chain reaction polymorphic preeclampsia pregnancies pregnant women Prenat Diagn prenatal diagnosis probe protocol red blood cells risk serum single cells slides specific stained technique tion transcervical trimester trophoblast trophoblast cells