Free Radicals, Antioxidants, Aging and Disease
Presents information from significant peer-reviewed studies showing that increased oxidative stress has an important role in numerous medical disorders. Describes current concepts of life expectancy, the aging process, and the presence of free radicals in biological systems. Explores the relationship between free radical and increased oxidative stress in medical disorders, including atherosclerosis, ischemia/reperfusion injury, pulmonary diseases, liver and kidney disorders, cancer, and neurodegenerative disorders.
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Life Span and Life ExpectancyCurrent
Their Presence in Biological
The Aging Process
9 other sections not shown
Acad Sci USA acid activity addition aging alpha-tocopherol antioxidant antioxidant enzymes apoptosis ascorbic atherosclerosis beta-carotene Biochem brain cancer catalase cells cellular Chem chronic cigarette smoking Clin Invest Clin Nutr concentration controls coronary Cu/Zn-SOD decreased diabetes diet dietary disease disorders effects Engl enzyme erythrocytes evidence formation free radicals function gene glutathione peroxidase hepatic human hydrogen peroxide hydroxyl radical immune important increased induced inhibited injury intake iron ischemia ischemia/reperfusion ischemic kidney Lancet levels lipid peroxidation lipoprotein liver lung macrophages mechanisms membrane metabolism mice mitochondrial mortality muscle myocardial Natl Acad Sci neurons neutrophils nitric oxide normal oxidase oxidative damage oxidative stress pathogenesis patients peroxynitrite plasma Proc Natl Acad production prostate protein pulmonary rats reaction reactive oxygen species recent reduced renal reperfusion reported respiratory risk factors role scavengers selenium serum significantly studies suggested superoxide dismutase supplementation tion tissue toxicity various vitamin vitro xanthine xanthine oxidase