From Basic Immunology to Immune-Mediated Demyelination

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Gianvito Martino, Luciano Adorini
Springer Science & Business Media, Mar 1, 1999 - Medical - 315 pages
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Morphological, physiological and pathological evidence demonstrates that ner­ vous and immune systems interact not only in maintaining brain homeostasis, but also in causing neurological diseases. The studyofthese interactions repre­ sents the basis on which neuroimmunologyhas grown during the years. At pre­ sent, several neurological diseases are recognized to be caused by a derange­ ment of the immune system in either its regulatory or effector functions. The main scope ofthis book, to discuss how an unbalanced immune system maylead to immune-mediated neurological diseases, is achieved in three parts. The first part provides an overview on how the immune system works. This is propaedeutical to understanding interactions between the immune and ner­ vous systems, which are discussed in the second part. The third part of the book focuses on one particular area of neuroimmunology, the immune disor­ ders leading to the damage of central and peripheral myelin. Given the opportunity to review first the immune system in itself and then how it operates during immune-mediated demyelinating disorders, we have tried to provide the reader with a basis for clearly understanding how interac­ tions between the immune and nervous systems can be protective or pathoge­ nic. This knowledge is a prerequisite for a rationale immune intervention tar­ geting these disorders.
 

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Contents

Protective Versus Harmful Responses and Immune Regulation
1
Antigen Recognition and Autoimmunity
7
Assembly and Function of Immunoglobulins During B Cell Development
16
I Pathogenetic Mechanisms of Autoimmunity
26
Adhesion Receptors Involved in Leukocyte Functions
38
The Endothelium of the Brain Microvasculature and the Organization of Intercellular Junctions
47
Chemokines and Chemokine Receptors
58
Th1Th2 Cytokine Network
68
Adhesion Molecules and the BloodBrain Barrier in Multiple Sclerosis
149
NonMyelin Antigen Autoreactivity in Multiple Sclerosis
162
Myelin Antigen Autoreactivity in Multiple Sclerosis
170
Inflammation and Multiple Sclerosis a Close Interplay
185
Magnetic Resonance and BloodBrain Barrier Dysfunction in Multiple Sclerosis
195
Immunotherapies for Multiple Sclerosis
210
Animal Models of Demyelination of the Central Nervous System
233
MHC and NonMHC Genetics of Experimental Autoimmune Encephalomyelitis
246

Antigen Presentation in the Central Nervous System
89
Myelination of the Central Nervous System
101
Genomic Screening in Multiple Sclerosis
116
MHC and Multiple Sclerosis
130
Cytokine Genes in Multiple Sclerosis
137
Genetics of Hereditary Neuropathies
265
Immunopathogenetic Role of AntiNeural Antibodies in Demyelinating Dysimmune Neuropathies
274
Treatment of Inflammatory Demyelinating Polyneuropathy
287
Subject Index
313
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