From DNA Damage and Stress Signalling to Cell Death: Poly ADP-ribosylation Reactions
Gilbert de Murcia, Sydney Shall
Oxford University Press, 2000 - Science - 238 pages
Over the last 10 years, it has become apparent that poly-ADP ribosylation reactions govern some of the fundamental processes of life. PARP 1 is a highly conserved enzyme and a constitutive factor of the DNA damage surveillance network and plays an essential role in the protection and processing of DNA ends as they arise in DNA damage, repair, and recombination. The recent discovery of multiple members of the PARP family suggests an expanded role for poly-ADP ribosylation reactions. PolyADP-ribosylation Reactions contains basic knowledge of poly-ADP ribosylation reactions and reviews the most recent molecular (including the crystal structure) and genetic (including knock out mice) approaches that have contributed to our understanding of the physiological role PARP 1 and its homologues. A discussion of the novel pharmacological role of inhibition of PARP is also included. The final chapter outlines future directions in the field of cellular responses to DNA damage. Its comprehensive coverage of the multiple aspects of this type of post-translational modification induced by DNA damage mean this book will serve as reference for both new and experienced investigators.
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ADPribose polymer metabolism
Biological significance of poly ADPribosylation
5 other sections not shown
3-aminobenzamide acceptor adenine adenosine diphosphate ribose ADP-ribose polymers ADP-ribosylation antibodies antisense RNA apoptosis apoptotic automodification base excision repair benzamide Berger Biochem Biochemistry Biol Biophys BRCT Cancer Res caspases catalytic domain cDNA cell death cell lines cellular Chem chromatin clones complex cytotoxicity depletion DNA breaks DNA damage DNA ligase DNA repair DNA strand breaks DNA-PK effect enzyme expression fibroblasts function genomic glycohydrolase histone induced inhibition inhibitors of PARP injury interaction involved Jacobson mammalian Menissier-de Murcia merase metabolism Miwa molecular molecules mouse Murcia mutant NAD+ Natl Acad necrosis NF-kB nicotinamide Niedergang nitric oxide nuclear PARG PARP activity PARP gene PARP inhibitors PARP-CF pathway peroxynitrite Poirier poly adenosine poly ADP poly ADP-ribose poly(ADP polymer polymerase potential Proc protein reaction recombination reperfusion replication residues role of PARP sequence signalling Smulson specific structure Sugimura synthesis synthetase Szabo telomere tion topoisomerase transcription tumour vitro vivo Wang wild-type XRCC1