From Egg to Embryo: Regional Specification in Early Development

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Cambridge University Press, May 30, 1991 - Medical - 328 pages
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The past decade has seen a dramatic increase in our understanding of early animal development. The revised edition of this excellent book describes the results of this revolution and explains in detail how the body plan of an embryo emerges from a newly fertilized egg. The book starts with a critical discussion of embryological concepts, and with simple mathematics describes cell states, morphogen gradients, and threshold responses. The experimental evidence of the mechanisms of regional specification in vertebrates, insects, and selected invertebrates, namely frogs (Xenopus), mice, chicks, fruitflies (Drosophila), mollusks, ringed worms, sea squirts, and nematode worms (Caenorhabditis), is then discussed. The progress with Drosophila has been particularly impressive, and there is an entire chapter devoted to it that provides a clear guide to the subject and includes a new table of developmentally important genes. Throughout, the emphasis is on conceptual clarity and unity, and the book brings together mathematical models, embryological experiments, and molecular biology in a single comprehensible and coherent account.
 

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Contents

III
1
IV
2
V
3
VI
4
VII
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VIII
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IX
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X
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XLI
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XLII
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XLVIII
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XXXVII
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L
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LXXI
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LXXIV
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Page 310 - Martin, GR (1981) Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
Page 314 - Schedl, P. (1989). Molecular analysis of the armadillo locus: Uniformly distributed transcripts and a protein with novel internal repeats are associated with a Drosophila segment polarity gene. Genes Dev.
Page 303 - Gospodarowicz D. , Ferrara N. , Schweigerer L. and Neufeld G. 1987. Structural characterization and biological functions of fibroblast growth factor. Endocrine Rev.
Page 307 - Jaenisch, R. , Ja'hner, D. , Nobis, P., Simon, I., Lohler, J., Harbers, K. and Grotkopp, D. (1981). Chromosomal position and activation of retroviral genomes inserted into the germ line of mice. Cell 24, 519-529.
Page 310 - McMahon AP, Bradley A (1990). The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain. Cell 62: 1073-1085.
Page 317 - Smith, AG, Heath, JK, Donaldson, DD, Wong, GG, Moreau, J., Stahl, M., and Rogers, D. (1988) Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides.

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