From Egg to Embryo: Regional Specification in Early Development
The past decade has seen a dramatic increase in our understanding of early animal development. The revised edition of this excellent book describes the results of this revolution and explains in detail how the body plan of an embryo emerges from a newly fertilized egg. The book starts with a critical discussion of embryological concepts, and with simple mathematics describes cell states, morphogen gradients, and threshold responses. The experimental evidence of the mechanisms of regional specification in vertebrates, insects, and selected invertebrates, namely frogs (Xenopus), mice, chicks, fruitflies (Drosophila), mollusks, ringed worms, sea squirts, and nematode worms (Caenorhabditis), is then discussed. The progress with Drosophila has been particularly impressive, and there is an entire chapter devoted to it that provides a clear guide to the subject and includes a new table of developmentally important genes. Throughout, the emphasis is on conceptual clarity and unity, and the book brings together mathematical models, embryological experiments, and molecular biology in a single comprehensible and coherent account.
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32-cell stage alleles amphibian animal hemisphere anteroposterior archenteron ascidians axis become bicoid blastocysts blastomeres blastula body plan cell lineage cell types cellular blastoderm Chapter chromosome cleavage clonal clones coding concentration cytoplasm cytoplasmic determinants defects developmental differentiation dorsal dorsoventral Drosophila early development ectoderm effect embryo embryology endoderm epidermis experimental experiments explants expression pattern extraembryonic fate map formation function gap genes gastrulation germ band gradient graft homeobox homeotic genes hypoblast injection interactions isolated labelled larva later layer marginal zone markers maternal mechanism mesenchyme mesoderm micromeres molecular morphogen mosaic mouse mRNA muscle mutant neural induction neural plate normal development notochord occur oocyte oogenesis organizer pair-rule genes parasegments phenotype pole cells pole plasm posterior primitive streak produce progeny prospective region protein regional specification sea urchin segment selector genes sequence signal similar somites stem cell stripes structures studies syncytial blastoderm tissue Transcription trophectoderm vegetal ventral vertebrate Xenopus zygotic
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