From a to [alpha]: Yeast as a Model for Cellular Differentiation
From a to&alphais a short supplemental textbook that uses control of yeast mating type as a model for many aspects of cell determination in general. Topics covered include gene silencing; genetic recombination; differentiation; combinatorial gene regulation; mRNA transport to establish asymmetric cell division; signal transduction; evolution of genetic networks; and various aspects of cell biology, including action of cytoskeleton and bud site selection. The book includes a foreword by Mark Ptashne, author of A Genetic Switch.
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Ch 4 Making and Secreting Cell Typespecific Signals
Ch 5 Detecting and Responding to a Signal
Ch 6 How Division of a Single Cell Can Produce Two Cell Types
Ch 7 Gene Silencing in the Control of Cell Type
Ch 8 Controlling Cell Polarity
Ch 9 Evolution of Cell Type Determination
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a-factor a-sgs acetylation active ADE2 albicans Ash1 Bem1 bind to DNA Bud1 budding pattern cell cycle cell division cell type–specific Chapter chromatin chromosome copies daughter cell deacetylated diploid DNA sequences DNA-binding enzymes eukaryotes Far1 Figure filamentous growth function Fus3 G protein G1 phase gene expression genome h-sgs haploid haploid cells haploid-specific genes histone tails HMRa homeodomain homologous Hox genes human Kex2 Kss1 loci lysine MAP kinase MAT locus MATa mating pheromone mating type mating-type locus mating-type switching Mcm1 Mcm1 dimer mechanism meiosis meiosis and sporulation molecules mother cell mRNA neoformans occurs organisms peptide pheromone phosphorylation plasma membrane produce promoter protein called pseudohyphal Rap1 recombination recruit regulators repressed repressor RME1 Saccharomyces cerevisiae shmoo shown silencing silent cassettes Sir complex Sir4 specific spores sporulation Ste2 Ste3 Ste5 Ste7 stem cell Tec1 tein telomeres undergo meiosis vesicles yeast yeast cells