Frontiers of Cord Blood Science

Front Cover
Niranjan Bhattacharya, Phillip Stubblefield
Springer Science & Business Media, Apr 21, 2009 - Medical - 400 pages

Cord blood is a significant source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Cord blood is also an alternative to embryos as a source of tissue for regenerative medicine. Cells from cord blood have been shown to transdifferentiate into nonhematopoietic cells, including those of the brain, heart, liver, pancreas, bone, and cartilage, in tissue culture and in animal systems. Recently it has been demonstrated that both cardiac and glial cell differentiation of cord blood donor cells occurred in recipients of unrelated donor cord blood transplantation as part of a treatment regime for Krabbe disease and Sanfilippo syndrome. These observations raise the possibility that cord blood may serve as a source of cells to facilitate tissue repair and regeneration in the future. CD34 stem cell-rich umbilical cord whole blood transfusion has the potential to have an immediate benefit of better tissue oxygenation with an additional delayed benefit of possible engraftment of umbilical cord stem cells.

 

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Contents

to 2 Cord Blood Stem Cells 0 The Basic Science
19
to 3 Stem Cells from Umbilical Cord Blood
27
to 4 Ex Vivo Expansion of Cord Blood
91
Applications in Cell and Gene Therapy
97
to 6 Nonhematopoietic Stem and Progenitor Cells Derived From Human Umbilical Cord Blood
123
Section II Umbilical Cord Blood Stem Cell Transplantation
158
to 8 Cord Blood Transplantation for Hematologic Malignancies
195
to 9 Double Umbilical Cord Blood Transplantation in Adults
209
to 11 Umbilical Cord Blood Therapy in Neurology
264
Opportunities and Challenges for the Reconstructive Surgeon
273
to 13 Umbilical Cord Blood Transfusion 0 A Clinical Overview
289
Section IV Cord Blood Stem Cell Banking
296
to 15 Cord Blood Allogeneic and Autologous Banking
307
Section V Potential Engineering Applicationof Cord Blood
316
to 17 Potential of Stem Cell to Tailor the BoneCeramic Interface for Better Fixation of Orthopedic Implants
331
Section VI Ethics
358

Section III Transfusion of Cord Blood
224

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