Frontiers in Eating and Weight Regulation

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Wolfgang Langhans, Nori Geary
Karger Medical and Scientific Publishers, 2010 - Medical - 208 pages
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The development of effective preventive and therapeutic measures to control eating and body weight involves basic physiology as well as cognitive and social psychology. The potential of molecular genetics to illuminate brain-behavior relationships became apparent with the discovery of the leptin gene in 1994. At present, molecular methodologies are being integrated with other physiological approaches, resulting in a number of options from which effective therapeutic strategies may evolve. This book highlights this exciting juncture: Fifteen leading experts present brief descriptions of some of the latest developments of the physiology of eating and weight regulation, ranging from endocrine and neural controls to genetics and functional brain imaging. These Frontier chapters are preceded by a general overview that provides requisite background on the physiology of eating as well as a conceptual framework for the Frontier chapters.Due to its special nature, this book will be of great interest to students at a variety of levels, to basic researchers already in the area or new to it, and to researchers and clinicians interested in translational issues.
 

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Contents

Basic and Clinical Approaches
1
Overview of the Physiological Controlof Eating
9
Therapeutic Potential of Gut Peptides
54
Roles of Amylin in Satiation Adiposity andBrain Development
64
The Enterocyte as an Energy Flow Sensor inthe Control of Eating
75
Development of Hypothalamic NeuralNetworks Controlling Appetite
84
Hypothalamic Nutrient Sensing and EnergyBalance
94
BloodBrain Barrier as a Regulatory Interface
102
HypothalamicBrainstem Circuits ControllingEating
133
Brainstem Integrative Function in the CentralNervous System Control of Food Intake
141
Gaining New Insights into Food Reward withFunctional Neuroimaging
152
Cortical Mechanisms of Human Eating
164
Genetic Variation in Dopaminergic Reward inHumans
176
Metabolic Imprinting in Obesity
186
GeneEnvironment Interactions in Obesity
195
Author Index
204

Do Leptin and Insulin Signal Adiposity?
111
LeptinSignaling Pathways and LeptinResistance
123

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