Functional Analysis of the Human Genome
Farzin Farzaneh, David N. Cooper
BIOS, Jan 1, 1995 - Medical - 275 pages
An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.
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Retroviral insertional mutagenesis F Farzaneh J Gaken
von Melchner H Laboratory of Molecular Hematology Department
Mapping the human genome D N Cooper
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activity adenovirus allele Alu sequences analysis animals antisense oligonucleotides binding Biol cell lines cellular DNA chromatin cleavage clones containing cosmid CpG islands cytogenetic disease DNA fragments DNA methylation DNA sequences Doerfler elements enhancer enzymes eukaryotic exon foreign DNA function fusion gene expression gene of interest gene product gene trap Genes Dev hamster cells homologous recombination HPRT human chromosome human genome identification imprinting inactivation infection intron isolation locus mammalian cells molecular molecules mouse mRNA murine mutations Natl Acad novo methylation Nucleic Acids Res oncogenes P-globin phenotype physical mapping plasmid polymerase primer probes Proc promoter protein provirus provirus integration receptor region regulation regulatory replication reporter gene retroviral ribozymes selectable marker somatic cell hybridization specific splicing structure studies synthesis target tissue-specific transcribed transcription factors transfection transgenic transgenic mice tumour upstream vectors viral DNA Virol virus vitro yeast artificial chromosomes