Functional Analysis of the Human GenomeAn excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures. |
Contents
Retroviral insertional mutagenesis F Farzaneh J Gäken | 4 |
von Melchner H Laboratory of Molecular Hematology Department | 7 |
Mapping the human genome D N Cooper | 43 |
Copyright | |
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activity Ad12 DNA adenovirus allele Alu sequences analysis animals antisense oligonucleotides binding Biol cDNA cell lines cellular DNA chromatin cleavage clones containing CpG islands cytogenetic disease DNA fragments DNA methylation DNA sequences Doerfler elements enhancer enzymes eukaryotic exon foreign DNA function fusion gene expression gene of interest gene product gene trap Genes Dev hamster cells homologous recombination HPRT human chromosome human genome identification imprinting inactivation infection intron isolation locus mammalian cells molecular molecules mouse mRNA murine mutations Natl Acad novo methylation Nucleic Acids Res oncogenes phenotype physical mapping plasmid polymerase primer probes Proc promoter protein provirus receptor region regulation regulatory replication reporter gene retroviral ribozymes RNase H somatic cell hybridization specific splicing ẞ-globin structure studies synthesis target transcribed transcription factors transfection transgenic transgenic mice tumour upstream vectors viral DNA Virol virus vitro yeast artificial chromosomes