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Discovery Chemistry and Action Hamao UMezawa
Mechanism of Action of Bleomycin Michiko Miyaki and Tetsuo Ono
Mode of Action on DNA W E G Muller and R K Zahn
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action of bleomycin action of BLM activity administration agents Antibiot antitumor bleomycin bleomycin BLM BLM A2 BLM and radiation BLM ointment BLM treatment Bowen's disease brain tumors Cancer Res cell cycle chemotherapy Clin combined treatment concentration of BLM dosage dose of BLM drug effect of bleomycin effect of BLM enzyme epidermoid esophageal carcinoma fraction G2 phase glioma histological Hodgkin's disease ig/ml inactivated incubation inhibition injection intravenous irradiation Japanese lesions lung cancer lymph node lymphoma malignant mammalian cells metastases Methotrexate mg of BLM mg/kg months mouse patients phleomycin Photo plateau phase polymerase preoperative Proc pulmonary fibrosis radiation therapy radiotherapy rads reaction regression reported resection sarcoma scission of DNA shown side effects skin squamous cell carcinoma strand scission surgery Table Takeuchi Terasima terminal amine moiety tion total dose toxicity treated with BLM treatment with BLM tumor cells tumor tissue Umezawa vinblastine vincristine vitro weeks