GPI Membrane Anchors
Academic Press, Dec 2, 2012 - Science - 320 pages
GPI Membrane Anchors reviews major advances in our understanding of glycosylphosphatidylinositol (GPI) membrane anchors. The book examines the GPI structure and its originality as an anchoring device, its ubiquitous distribution, the main steps of its biosynthetic pathway, and the elegant means by which a protein signals for GPI attachment. It also presents evidence for the uniqueness of GPI as a tag in intracellular traffic and as a mediator of transmembrane signaling.
This volume is organized into 20 chapters and begins with a discussion of the structural requirements of a nascent protein for processing to a PI-G anchored form, with emphasis on experiments on intact cells and cell-free systems. It then turns to the mechanisms underlying signal transduction by GPI-anchored membrane proteins, the LY-6 superfamily of GPI-anchored molecules, and glycosylated-phosphatidylinositols as virulence factors in Leishmania. The reader is also introduced to the molecular biology of GPI-anchored border hydrolases, the role of GPIs and their inositolglycan derivatives in the mediation of insulin and growth factor function, and biosynthesis and cellular localization of GPI-modified glycoproteins in Saccharomyces cerevisiae. An account of electrospray mass spectrometry of a C-terminal peptide purified from the scrapie isoform of the scrapie prion protein is also given. The book concludes with a chapter on GPI-anchored recognition molecules that function in axonal fasciculation, growth, and guidance in the nervous system.
This book is a valuable resource for students and researchers in the fields of cell biology and biochemistry.
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CHAPTER 3 EMERGENCE OF THE LY6 SUPERFAMILY OF GPIANCHORED MOLECULES
CHAPTER 4 GLYCOSYLATEDPHOSPHATIDYLINOSITOLS AS VIRULENCE FACTORS IN LEISHMANIA
CHAPTER 5 WHY DO SO MANY SURFACE PROTEINS OF TRYPANOSOMATIDS HAVE GPIANCHORS?
CHAPTER 6 PROBING THE SIGNAL FOR GLYCOPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT USING DECAY ACCELERATING F...
CHAPTER 7 INOSITOLGLYCANS AND CELLULAR SIGNALLING
CHAPTER 8 ELECTROSPRAY MASS SPECTROMETRY OF THE GLYCOSYIINOSITOL PHOSPHOLIPID OF THE SCRAPIE PRION PROTEIN
CHAPTER 12 BIOSYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL
CHAPTER 13 POLARIZED SORTING OF GPILINKED PROTEINS IN EPITHELIA AND MEMBRANE MICRODOMAINS
CHAPTER 14 EVALUATION OF SOMATIC CELL VARIANTS DEFICIENT IN GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORING AS CAN...
CHAPTER 15 BIOCHEMICAL AND FUNCTIONAL CHARACTERIZATION OF A GLYCOLIPID ANCHORED CELL ADHESION MOLECULE I...
CHAPTER 16 THE MOLECULAR BIOLOGY OF GPIANCHORED BORDER HYDROLASES
CHAPTER 17THE BIOLOGY OF THE GLYCOSYLPHOSPHATIDYLINOSITOLSPECIFIC PHOSPHOLIPASE C OF TRYPANOSOMA BRUCEI
CHAPTER 18 BACTERIAL PIPLCS UNIQUE PROPERTIES AND USEFULNESS IN STUDIES ON GPI ANCHORS
FATTY ACID ACYLATION OF INOSITOL
CHAPTER 9 BIOSYNTHESIS OF GLYCOPHOSPHOINOSITOL ANCHORS IN SACCHAROMYCES CEREVISIAE
CHAPTER 10 CHARACTERIZATION OF THE PLASMA GLYCOSYLPHOSPHATIDYLINOSITOLSPECIFIC PHOSPHOLIPASE D GPIPLD
CHAPTER 11 EVOLUTIONARY ASPECTS OF GPI METABOLISM IN KINETOPLASTID PARASITES
CHAPTER 20 GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED RECOGNITION MOLECULES THAT FUNCTION IN AXONAL FASCICUL...
Acad acetylcholinesterase activity acylation alkaline phosphatase amino acid anchored proteins antibodies antigen apical attachment bacterial PIPLCs basolateral Bﬁlow Biochem Biochemistry biosynthesis brucei variant surface C-terminal cDNA Cell Biol cell line cell surface cellular Chem cleavage cloning Conzelmann COOH-terminal cytoplasmic dipeptidase enzyme epitope ethanolamine expression fatty acid Ferguson function gene GIPLs glycan glycolipid glycosyl glycosyl-phosphatidylinositol GPI anchor GPI-anchored proteins Homans hydrophobic hydrophobic domain Ikezawa inositol inositolglycan insulin intracellular isoform kidney labelled lanes Leishmania lipid Lisanti mammalian mannose McConville MDCK cells mediators membrane anchor membrane proteins Menon meSG moiety molecular molecules mutant Natl NCAM Overath parasites pathway peptide phosphatidylinositol phosphatidylinositol-specific phospholipase phospholipase PI-G tailed PLAP plasma membrane polarized precursor prion Proc promastigotes protease purified receptor release residues Saltiel scrapie sequence signal soluble specific structure substrate sVSG synthesis Taguchi Thy-l transfected transmembrane Trypanosoma brucei Trypanosoma brucei variant trypanosomes Turco variant surface glycoprotein