GPI Membrane Anchors

Front Cover
M Almeida
Academic Press, Dec 2, 2012 - Science - 320 pages
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GPI Membrane Anchors reviews major advances in our understanding of glycosylphosphatidylinositol (GPI) membrane anchors. The book examines the GPI structure and its originality as an anchoring device, its ubiquitous distribution, the main steps of its biosynthetic pathway, and the elegant means by which a protein signals for GPI attachment. It also presents evidence for the uniqueness of GPI as a tag in intracellular traffic and as a mediator of transmembrane signaling.
This volume is organized into 20 chapters and begins with a discussion of the structural requirements of a nascent protein for processing to a PI-G anchored form, with emphasis on experiments on intact cells and cell-free systems. It then turns to the mechanisms underlying signal transduction by GPI-anchored membrane proteins, the LY-6 superfamily of GPI-anchored molecules, and glycosylated-phosphatidylinositols as virulence factors in Leishmania. The reader is also introduced to the molecular biology of GPI-anchored border hydrolases, the role of GPIs and their inositolglycan derivatives in the mediation of insulin and growth factor function, and biosynthesis and cellular localization of GPI-modified glycoproteins in Saccharomyces cerevisiae. An account of electrospray mass spectrometry of a C-terminal peptide purified from the scrapie isoform of the scrapie prion protein is also given. The book concludes with a chapter on GPI-anchored recognition molecules that function in axonal fasciculation, growth, and guidance in the nervous system.
This book is a valuable resource for students and researchers in the fields of cell biology and biochemistry.
 

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Contents

STUDIES IN INTACT CELLS AND CELLFREE SYSTEMS
1
CHAPTER 2 SIGNAL TRANSDUCTION BY GPIANCHORED MEMBRANE PROTEINS
22
CHAPTER 3 EMERGENCE OF THE LY6 SUPERFAMILY OF GPIANCHORED MOLECULES
29
CHAPTER 4 GLYCOSYLATEDPHOSPHATIDYLINOSITOLS AS VIRULENCE FACTORS IN LEISHMANIA
38
CHAPTER 5 WHY DO SO MANY SURFACE PROTEINS OF TRYPANOSOMATIDS HAVE GPIANCHORS?
58
CHAPTER 6 PROBING THE SIGNAL FOR GLYCOPHOSPHATIDYLINOSITOL ANCHOR ATTACHMENT USING DECAY ACCELERATING F...
73
CHAPTER 7 INOSITOLGLYCANS AND CELLULAR SIGNALLING
85
CHAPTER 8 ELECTROSPRAY MASS SPECTROMETRY OF THE GLYCOSYIINOSITOL PHOSPHOLIPID OF THE SCRAPIE PRION PROTEIN
111
CHAPTER 12 BIOSYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL
155
CHAPTER 13 POLARIZED SORTING OF GPILINKED PROTEINS IN EPITHELIA AND MEMBRANE MICRODOMAINS
170
CHAPTER 14 EVALUATION OF SOMATIC CELL VARIANTS DEFICIENT IN GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORING AS CAN...
197
CHAPTER 15 BIOCHEMICAL AND FUNCTIONAL CHARACTERIZATION OF A GLYCOLIPID ANCHORED CELL ADHESION MOLECULE I...
211
CHAPTER 16 THE MOLECULAR BIOLOGY OF GPIANCHORED BORDER HYDROLASES
229
CHAPTER 17THE BIOLOGY OF THE GLYCOSYLPHOSPHATIDYLINOSITOLSPECIFIC PHOSPHOLIPASE C OF TRYPANOSOMA BRUCEI
246
CHAPTER 18 BACTERIAL PIPLCS UNIQUE PROPERTIES AND USEFULNESS IN STUDIES ON GPI ANCHORS
260
FATTY ACID ACYLATION OF INOSITOL
276

CHAPTER 9 BIOSYNTHESIS OF GLYCOPHOSPHOINOSITOL ANCHORS IN SACCHAROMYCES CEREVISIAE
121
CHAPTER 10 CHARACTERIZATION OF THE PLASMA GLYCOSYLPHOSPHATIDYLINOSITOLSPECIFIC PHOSPHOLIPASE D GPIPLD
132
CHAPTER 11 EVOLUTIONARY ASPECTS OF GPI METABOLISM IN KINETOPLASTID PARASITES
140
CHAPTER 20 GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED RECOGNITION MOLECULES THAT FUNCTION IN AXONAL FASCICUL...
294
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