Gastrointestinal Inflammation and Disturbed Gut Function: The Challenge of New Concepts

Front Cover
G. Holtmann, N.J. Talley
Springer Science & Business Media, Sep 30, 2003 - Medical - 290 pages

In gastrointestinal (GI) practice, a large proportion of patients present with what are currently classified as functional GI complaints. For decades, psychological causes have been implicated in the initiation and maintenance of symptoms. In recent years, disturbances of GI function including sensory motor abnormalities have been catalogued and are now believed to play a key role in the development of symptoms. A genetic predisposition may be important. Furthermore, evidence has accumulated that GI inflammation can trigger and maintains functional disturbances. In particular, acute GI inflammation appears to play a crucial role in at least a subgroup of patients. These observations potentially have profound implications for the field, and suggest that functional GI disorders are indeed organic diseases.

This book, the proceedings of Falk Symposium 130 on 'Gastrointestinal Inflammation and Disturbed Gut Function: The Challenge of New Concepts', held in Freiburg, Germany, on October 4-6, 2002 (Part I of the Gastroenterology Week Freiburg 2002), reviews ground-breaking work and will stimulate new research in the functional GI disorders, from the bench to the bedside. Basic scientists, clinical researchers and clinicians interested in this field explore controversial and exciting areas of research, and consider targets for future therapeutic interventions.

 

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Contents

Epidemiology of functional bowel disease and inflammatory bowel disease a common link?
3
Extraintestinal manifestations and psychiatric illness in irritable bowel syndrome is there a link?
10
Evidence of bidirectional crosssensitization of the distal colon and lower urinary tract a possible aetiology of concurrent irritable bowel syndrome an...
17
Are dissociative mental disturbances responsible for visceral hyperalgesia in patients with functional abdominal pain?
29
Current knowledge regarding the initiation and regulation of gastrointestinal inflammation in inflammatory bowel disease
35
Is the normal gut inflamed? And does it matter?
44
Symptomatic inflammatory bowel disease in remission it could be irritable bowel syndrome
53
The symptomatic IBD patient in remission a manifestation of IBS? Cons
57
Neuroimmunology and the gastrointestinal tract
160
Visceral hypersensitivity in functional gastrointestinal disorders
169
Motor function and dysfunction in functional dyspepsia and irritable bowel syndrome
176
A rational approach to Helicobacter pylori eradication in patients with functional dyspepsia
187
Con Helicobacter pylori eradication a rational approach for the treatment of patients with functional dyspepsia?
196
Animal models for visceral sensitivity
205
Descending modulation of visceral hyperalgesia
213
Epidemiology and clinical impact of postinfectious irritable bowel syndrome
223

Herbal preparation in functional dyspepsia Helicobacter pylori status is not a predictor for treatment success results of a doubleblind randomized pla...
62
Intestinal gas dynamics and tolerance are modified by the different components of nutrients
70
Vagal afferents and regulation of inflammation and hyperalgesia in remote body domains
79
Inflammationinduced changes in nerves as a basis for symptom generation in irritable bowel syndrome
104
Inflammationinduced altered nerve function in the gut does it play a role in gastrointestinal symptom generation?
109
Colonic spinal primary afferents mechanosensory and chemosensory subtypes and effects of inflammation
120
Regulation of vagal afferent sensitivity to gastric acid
126
Alterations of the enteric nervous system and interstitial cells of Cajal in functional colorectal motility disorders
136
Sensory nerve function in gut inflammation
151
Potential mechanisms and therapeutic implications of bacterial infection in irritable bowel syndrome
229
Role of epitheliumenvironment interactions in downregulation of mucosal inflammation
239
Is irritable bowel syndrome a genetic disorder?
245
Localization and functions of neurokinin and Nmethyl Daspartate receptors
253
Replacing physiological variability by genetic variability from gene to function
260
Gut function and dysfunction in functional gastrointestinal disorders a personal view
269
Index
277
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