Gene Vaccines

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Josef Thalhamer, Richard Weiss, Sandra Scheiblhofer
Springer Science & Business Media, Aug 31, 2011 - Medical - 330 pages
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The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
 

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Contents

General Mechanisms of Gene Vaccines
1
Strategies to Improve DNA Vaccine Potency HPVAssociated Cervical Cancer as a Model System
37
ImmuneActivating Mechanisms of ReplicaseBased DNA and RNA Vaccines and Their Role in ImmuneApoptosis
67
Cytokine Genes as Molecular Adjuvants for DNA Vaccines
89
Pharmaceutical NonViral Formulations for Gene Vaccines
109
Rational Design of Formulated DNA Vaccines The DermaVir Approach
127
Improvement of DNA Vaccines by Electroporation
145
Electroporation Based TriGrid Delivery System TDS for DNA Vaccine Administration
163
Intralymphatic Vaccination
205
Messenger RNA Vaccines
223
DNA and RNA Vaccines for Prophylactic and Therapeutic Treatment of Type I Allergy
247
Approved Veterinary Vaccines Paving the Way to Products for Human Health
265
Current Status of Regulations for DNA Vaccines
285
MinicircleDNA
297
Industrial Manufacturing of PlasmidDNA Products for Gene Vaccination and Therapy
311
Copyright

Prime Boost Regimens for Enhancing Immunity Magnitude Quality of Mucosal and Systemic Gene Vaccines
183

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