Genetic Factors in Drug Therapy: Clinical and Molecular Pharmacogenetics

Front Cover
Cambridge University Press, Dec 16, 1993 - Medical - 657 pages
This is the first comprehensive work of reference to survey in depth the wide-ranging variability in the response of individuals to drugs.
 

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Contents

Classification of pharmacogenetic phenomena
6
Arylhydrocarbon hydroxylase cytochrome P450 1A1 and 1A2
19
The mephenytoin hydroxylation polymorphism cytochrome P450 2C18
35
The debrisoquinesparteine polymorphism cytochrome P450 2D6
54
Tolbutamide
113
Phenytoin
119
Some other drugs of special interest
132
Alcohol and alcoholism
177
The hepatic porphyrias
423
Malignant hyperthermia
459
Miscellaneous systems showing genetic variability in response to drugs
489
Glucocorticosteroids and intraocular pressure
499
Unstable haemoglobins
507
Human lymphocyte antigens and adverse reactions to drugs
512
The polymorphism for tasting phenylthiocarbamide PTC
518
Hereditary anticoagulant resistance
547

NAcetyltransferase
211
Miscellaneous Phase II reactions showing genetic variability in drug metabolism
303
GlutathioneStransferase
317
Methylation reactions
330
ParaoxOnase
346
Sulphotransferases
364
Sulphoxidation deficiency
371
Halothane hepatitis and other topics
382
Glucose6phosphate dehydrogenase deficiency
391
NADHcytochrome b5 reductase
555
Catalase
568
Antibioticinduced deafness chloramphenicol toxicity and other topics
574
Polygenic effects in pharmacogenetics
585
Common themes
593
Conclusions
615
Index
629
Copyright

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