Genetic Medicine: A Logic of Disease

Front Cover
Genetics, writes Barton Childs, M.D., is a biological science that, unlike biochemistry and physiology, developed and prospered outside medicine, and, until recent decades, overlapped with the latter only occasionally in regard to rare diseases. But now, ... molecular genetics is exposing medicine to genetic concepts that provide new ways to think about disease, its causes and its pathogenesis. So we have no choice but to examine how the ideas of genetics are influencing medical thinking today, how they should do so, and how we might use them to make medical education more relevant to what is happening in communities no less than in laboratories. In Genetic Medicine: A Logic of Disease, Dr. Barton Childs evaluates how knowledge of the contributions to disease of both genes and experiences provides a rational basis for medical thinking. This genetic medicine, he explains, should help the physician to use the result of the laboratory to perceive the uniqueness of the patient as well as that of the family and the cultural conditions in which the patient's condition was engendered. He thus provides a conceptual framework within which to teach and practice a humane medicine. Genet
 

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Contents

Preface
Acknowledgments
1Introduction
IMedical Thinking
2Inborn Errors and Chemical Individuality
3The Transition from Oslerian to Garrodian Medicine
4Individuality and Causes
5Definitions of Disease
16Whatever Is Is Variable
17The Semantics of Genetics
18Classification of Disease
VIReproduction Frequency and Continuity
19The Diploid State
20Gene Frequency
21Heterogeneity
22Unity and Continuity of Disease

IIA Logic of Disease
6Biology and MedicineContrasts and Convergences
7A Synthesis
IIISpecies Identity
8Lessons from Phylogeny
Homeostasis and Development
9Physiological HomeostasisThe Homeostasis of the Moment
10Genetic HomeostasisThe Past
11Developmental HomeostasisThe Lifetime
12Sociocultural Homeostasis
13Homeostatic Interactions
Genetic Variation
14What Is a Gene?
15The Paths of Gene Action
23Heritability
24Infections
VIIAn Analysis of Disease in Three Time Frames
25The MomentType I Diabetes
26The Lifetime
27Biology and Social History and a Vision of Disease in Three Time Frames
VIIIThe Logic and Modern Medicine
28The Human Genome Project
29The MedicalGenetic Synthesis and Society
30A Basis for Medical Education
Notes
Index
Copyright

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About the author (1999)

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Barton Childs, M.D., is professor emeritus of pediatrics and biology at the Johns Hopkins University School of Medicine.

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