Genetic Variation: A Laboratory Manual

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Michael P. Weiner, Stacey B. Gabriel, J. Claiborne Stephens
Cold Spring Harbor Laboratory Press, 2007 - Medical - 472 pages

Genetic Variation: A Laboratory Manualis the first compendium of protocols specifically geared towards genetic variation studies, and includes thorough discussions on their applications for human and model organism studies. Intended for graduate students and professional scientists in clinical and research settings, it covers the complete spectrum of genetic variation—from SNPs and microsatellites to more complex DNA alterations, including copy number variation. Written and edited by leading scientists in the field, the early sections of the manual are devoted to study design and generating genotype data, the use of resources such as HapMap and dbSNP, as well as experimental, statistical, and bioinformatic approaches for analyzing the data. The final sections include descriptions of genetic variation in model organisms and discussions of recent insights into human genetic ancestry, forensics, and human variation.

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Contents

The Global Experience
1
The raw material of genetic research is DNA individualtoindividual variation is the prism through which it is ana
2
STUDY DESIGN
11
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