Genetic Variation and Dietary Response
Artemis P. Simopoulos, P. J. Nestel
Karger, 1997 - Science - 171 pages
This timely volume focuses on genetics and nutrition, and their interaction in the development of chronic diseases. Knowledge of genetic susceptibility to disease will not only help to identify those at higher risk for disease but also to ascertain their response to diet. The prospect of targeting specific dietary treatment at those predicted to gain the most therapeutic benefit clearly has important clinical and economic consequences, particularly in diseases of high prevalence. This book is unique in considering genetic variation in susceptibility to disease, and the importance of specific diets in influencing lipid levels in cardiovascular disease and bone density in osteoporosis. The contributions emphasize that dietary response is dependent on the genetic variant and that specific dietary recommendations rather than universal ones are needed for the prevention and management of chronic diseases. Bringing together vital information for the first time, this book is important reading for physicians, nutritionists, dietitians, geneticists, physiologists, molecular biologists, food technologists and policymakers.
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activity Acylation-Stimulating Protein adipocytes adipose tissue allele apoB apoE apolipoprotein Arterioscler Thromb Arteriosclerosis associated Atherosclerosis baboons bile acid synthesis bone density bone mass Bone Miner calcium catabolism cells CETP cholesterol absorption cholesterol and fat cholesterol levels cholesterol response cholesterol synthesis chylomicron Clin Invest combined hyperlipidemia correlated dense LDL dietary cholesterol dietary fat dietary response differences effects endothelial enzyme familial fat and cholesterol fatty acids genotype glucose HDL1 hepatic cholesterol hepatic lipase high-cholesterol high-fat diet human hyperapoB hypercholesterolemia increased insulin intake interaction Kushwaha LDL apoB LDL cholesterol LDL particle LDL receptor LDL subclass Lipid Lipid Res lipoprotein lipase lipoprotein metabolism liver low density lipoprotein low-density lipoprotein low-fat normal obesity osteocalcin osteoporosis pathway patients phenotype plasma plasma cholesterol plasma lipid plasma triglyceride polymorphism rabbits regulation response to dietary role serum cholesterol studies trait triglyceride triglyceride synthesis twins variability VDR gene alleles Vitamin D receptor VLDL