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acid sequence activity alleles amino acid amlno amplification analysis Arabidopsis assay associated binding Biol cancer carcinoma cDNA cell lines Cent characterization chromo clones codon coll containing deletion detected differentiation disease DNA sequence domain Drosophila effects embryo En;en En.cn En.en enzyme exon factor fragment function gene encoding gene expression genetic genome genotypes growth homologous hybridization identified induced infection Inst intron involved isolated ISSN kinase levels linkage loci locus maize mapping markers membrane mice microsatellite mitochondria molecular mouse mRNA mutations NATL normal novel nucleotide patients pattern phenotype plant polymerase polymorphism populations probe protein receptor recombination region regulation resistance revealed role showed Southern blot species strains structure subunit suggest suppressor syndrome tion tissues traits transcription transcription factor transgenic tumor tumor suppressor gene Univ variation virus vitro vivo wild-type yeast