Genetics and Cancer Susceptibility: Implications for Risk Assessement
Specialists in their respective fields review the impact of both intrinsic genetic factors and extrinsic modifiers on human cancer risk. The book's main thrust is on susceptibility factors that are targets for chemical carcinogens, intrinsic factors that modify cancer risk and biomonitoring and extrinsic risk modification.
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The Role of p53 Loss in Genomic Instability
Genetic Susceptibility to In Vivo and In Vitro Chemical
Regulates MNUInduced Thymic Lymphoma Development
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acetylators activity aflatoxin agents AKR/J allele alterations analysis biomarkers bladder cancer BRCA1 breast cancer Canc Cancer Res cancer risk cancer susceptibility carcinogenesis carcinogens cDNA cell carcinoma chemical chromosome cloning codon dietary DNA adducts DNA repair Drinkwater Eker Environ Mol Mutagen environmental epidemiological exposure factors foci frequency genetic susceptibility genomic genotype H-ras hepatic hepatocarcinogenesis hepatocellular carcinomas Hrasl human IARC identified inbred incidence induced K-ras Kadlubar FF lacZ liver tumors locus lung cancer lymphoma mammary mammary tumors markers metabolism molecular mouse skin murine Mutagen mutation assays Natl oncogenes p53 gene p53 mutations papillomas pathways phenotype polymorphism preneoplastic Proc protein protooncogene renal cell carcinoma Risk Assessment rodent role SENCAR sensitive skin tumor Slaga spontaneous squamous cell SSIN studies TG p53+ tissue transgenic transgenic mice transgenic mouse mutation tumor development tumor promotion tumor suppressor gene tumorigenesis urinary vitro vivo Wnt-1 TG xeroderma pigmentosum