Genetics and Molecular Biology of Rhythms in Drosophila and Other Insects
Biological rhythms, such as the sleep-wake cycle or circadian clock, are an intriguing aspect of biology. The regulation of daily rhythmicity has long been a mystery, up until the mid-1980's when a key gene in the fruitfly, Drosophila melanogaster, was molecularly identified. Genetic and molecular chronobiology of Drosophila has been a driving force in this field of inquiry ever since. This book describes and evaluates all of the studies of this sort, discussing the manner by which these investigations have spread out in various directions of rhythmic biology, including genetic and molecular approaches used on other insect species.
* Discusses rhythm genetics in insects, from early investigations to current state-of-the-art
* Presents all relevant mutants and genes
* Highlights the mystery of the "clock mechanism" in full detail including the remaining puzzles to be solved
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5'-flanking abnormalities abundance activity adult allele amino-acid arrh arrhythmic axons Biol biological brain cause cDNA cells chromosome chronobiological circadian clock circadian rhythms clock genes clock-gene cloned color insert compound eye cryb cryptochrome daily cycle defects deletion disco dorsal Drosophila melanogaster E-box eclosion effects encoding entrainment etal exhibited expression Figure flies fluctuations fly's free-running periods function GAL4 gene products gene's genetic Hardin Helfrich-Forster immunoreactivity induced inferred insect interactions intron involved Kaneko and Hall kinase Konopka Kyriacou larval LD cycles levels light located locomotion locomotor rhythmicity locus mediated molecular molecules mRNA mutant neurons normal observed optic lobe oscillations pacemaker peak per's per+ per0 per1 period gene phase phenotypes photoreceptors polypeptide protein region regulation regulatory rhythm-related Rosbash Rothenfluh Sauman Section Sehgal sequences signals species Stanewsky strains Table temperature temporal tested tim0 timeless timeless gene tissues transcription factor transgene transposon variants wild-type
Current Topics in Developmental Biology, Volume 78
Limited preview - 2011