Germfree and Gnotobiotic Animal Models: Background and Applications

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CRC Press, Jun 19, 1996 - Medical - 208 pages
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The germfree animal is reared in the laboratory to be bacteria free; its counterpart, the gnotobiotic animal, is exposed to select microorganisms. The need for such an animal model for use in biomedical studies was first expressed by Pasteur in the late 1800s. Subsequent development of germfree and gnotobiotic animals led to an explosion of studies on the effects of microflora and its components on the physiology and metabolism of the host. Germfree and Gnotobiotic Animal Models brings together the most notable points of early and recent studies and gives reference to the most pertinent literature.
 

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Contents

Introduction
1
Early Growth Body Weight Reproduction and Life Span
9
Chapter III
19
Chapter IV
43
Chapter V
71
The Chemically Defined Diet
89
Chapter VII
101
Chapter VIII
127
Pathology Over the Life Span of the Germfree Rat and the Germfree
135
Chapter X
145
Chapter XI
154
Past Present and Future Part II Use of the Gnotobiote
161
Chapter XII
181
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Page 34 - LUCKEY. 1954. Use of the germfree animal technic in the study of experimental dental caries. I. Basic observations on rats reared free of all microorganisms.

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