Glutathione In The Nervous System
Christopher Ari Shaw
CRC Press, Feb 27, 1998 - Science - 389 pages
The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.
Multiple Roles of Glutathione in the Nervous System
The Discovery of the GSH Receptor in Hydra and
CarrierMediated GSH Transport at the BloodBrain
Role of Astrocytes in Maintaining Cerebral Glutathione
Glutathione and the Regulation of Apoptosis in
Possible Modulation by Glutathione of Glutamatergic
Medicinal Chemistry of Glutathione and Glutathione Analogs
Glutathione in Brain Aging and Neurodegenerative Disorders
The Glutathione Redox State and Zinc Mobilization from
Glutathione Release and Nitrosoglutathione Presence in
The Role of Altered Glutathione Status in the Development
FreeRadical Toxicity in Amyotrophic Lateral Sclerosis
Excitatory Actions of GSH on Neocortex
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Page 379 - Gurney, ME, Pu, H., Chiu, AY, Dal Canto, MC, Polchow, CY, Alexander, DD, Caliendo, J., Hentati, A., Kwon, YW, Deng, HX, Chen, W., Zhai, P., Sufit, RL, and Siddique, T.
Page 381 - NA, Vaillancourt, JP, Ding, CK, Gallant, M., Gareau, Y, Griffin, PR, Labelle, M., Lazebnik, YA, Munday, NA, Raju, SM, Smulson, ME, Yamin, T.-T, Yu, VL, and Miller, DK (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis, Nature 376, 37-43.