Glutathione In The Nervous System

Front Cover
Christopher Ari Shaw
CRC Press, Feb 27, 1998 - Science - 389 pages
The goal of this text is to focus readers attention on three major areas; the origin and localization of GSH in the nervous system; the multiple effects of GSH on neural health activity; and the potential for alterations on GSH status to lead to neurological damage of the type observed in amyotrophic lateral sclerosis, Parkinson's disease and other neurological disorders. The text also touches upon the additional roles of the antoxidant GSH, including possible neurotransmitter action, redox modulation of ionotropic receptor function, and neuroprotection against exicitoxic actions of glutamate.
 

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Contents

Multiple Roles of Glutathione in the Nervous System
3
The Discovery of the GSH Receptor in Hydra and
25
CarrierMediated GSH Transport at the BloodBrain
45
Production Characterization
63
Role of Astrocytes in Maintaining Cerebral Glutathione
91
Glutathione and the Regulation of Apoptosis in
117
Possible Modulation by Glutathione of Glutamatergic
137
Excitatory Actions of GSH on Neocortex
197
Glutathione in Brain Aging and Neurodegenerative Disorders
231
The Glutathione Redox State and Zinc Mobilization from
257
Glutathione Release and Nitrosoglutathione Presence in
275
The Role of Altered Glutathione Status in the Development
287
FreeRadical Toxicity in Amyotrophic Lateral Sclerosis
343
Is Glutathione
355
Index
385
Copyright

Medicinal Chemistry of Glutathione and Glutathione Analogs
217

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Page 379 - Gurney, ME, Pu, H., Chiu, AY, Dal Canto, MC, Polchow, CY, Alexander, DD, Caliendo, J., Hentati, A., Kwon, YW, Deng, HX, Chen, W., Zhai, P., Sufit, RL, and Siddique, T.
Page 376 - Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures.
Page 381 - NA, Vaillancourt, JP, Ding, CK, Gallant, M., Gareau, Y, Griffin, PR, Labelle, M., Lazebnik, YA, Munday, NA, Raju, SM, Smulson, ME, Yamin, T.-T, Yu, VL, and Miller, DK (1995) Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis, Nature 376, 37-43.

About the author (1998)

Shaw\, Christopher Ari

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