Growth Factors in Mammalian Development
The purpose of this volume is to review and discuss key growth factor systems that have been implicated in embryogenesis. Emphasis is placed on the insulin family of peptides, including insulin and the structurally and functionally related insulin-like growth factors. The initial chapters provide a review of basic topics, including developmental genetics, energy metabolism and hormonal signaling mechanisms, which are important prerequisites to the central theme that follows. The book concludes with a brief review of oncogene expression in early development; this new field has contributed significantly to our understanding of how mitogenic signals activate genetic elements responsible for embryonic growth and development. This book presents information important to cell biologists, endocrinologists, biological chemists, and developmental biologists.
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Control of Carbohydrate Metabolism in Preimplantation Mammalian Embryos
The Role of Protein Phosphorylation in Early
Insulin and InsulinLike Growth Factors IGFs in Avian Development
Acad affinity amino acid antibodies autocrine beta Biochem Biol blastocyst blastomeres cell types cellular Chem chick chicken embryo chromosome culture detected developmental differentiated cells Drosophila early mammalian early mouse embryos EC cell lines EGF receptor eggs embryogenesis encoding endoderm enzyme epidermal growth factor extracellular matrix extraembryonic fertilization fetal function genetic gestation glucose growth factor receptors growth factors produced hormone human IGF-I IGF-I receptor inactivation induce inhibit inhibitor insulin and IGFs insulin binding insulin receptor insulin-like growth factor insulin-related ligand mammalian development mammalian embryo maternal membrane metabolism morula mRNA MRP/PLF Natl Nature London oncogenes oocytes pancreas PC-13 EC cells PDGF peptide phosphorylation placenta platelet-derived growth factor preimplantation embryos preimplantation mouse embryo Proc protein kinase pyruvate regulation Rizzino role sequence shown specific stage stimulates structure studies subunit suggest synthesis teratocarcinoma TGF-o tissues transforming growth factor tyrosine kinase tyrosine kinase activity uptake vitro Xenopus oocytes