Guide to Human Genome Computing

Front Cover
Martin J. Bishop
Academic Press, Mar 25, 1998 - Science - 306 pages

The Guide to Human Genome Computing is invaluable to scientists who wish to make use of the powerful computing tools now available to assist them in the field of human genome analysis. This book clearly explains access and use of sequence databases, and presents the various computer packages used to analyze DNA sequences, measure linkage analysis, compare and align DNA sequences from different genes or organisms, and infer structural and functional information about proteins from sequence data.

This Second Edition contains completely updated material. Rather than a revision of the previous volume, the Second Edition is essentially a new book, based on the subjects which will be of interest over the coming years. This new book is international, both in scope and authorship.

  • Computing resources for the following are clearly explained: Internet resources - databases etc.
  • Genetic analysis
  • Sib-pair studies
  • Comparative mapping
  • Radiation hybrids
  • Sequence ready clone maps
  • Human genome sequencing
  • ESTs
  • Gene prediction
  • Gene expression
 

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Contents

Chapter 1 Introduction to Human Genome Computing Via the World Wide Web
1
Chapter 2 Biological Materials and Services
41
Chapter 3 Managing Pedigree and Genotype Data
49
Chapter 4 Linkage Analysis Using Affected SibPairs
75
Chapter 5 Comparative Mapping in Humans and Vertebrates
89
Chapter 6 Radiation Hybrid Mapping
113
Chapter 7 Sequence Ready Clone Maps
151
Chapter 8 Software for Human Genome Sequencing
181
Chapter 9 Human EST Sequences
205
Chapter 10 Prediction of Human Gene Structure
215
Putting the Parts Together
261
Chapter 12 GeneExpression Databases
275
Index
295
Copyright

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About the author (1998)

Martin Bishop works for the British Medicinal Resource Council as Bioinformatics Manager at the U.K. Human Genome Mapping Project Resource Centre.