HLA and the Maternal-Fetal Relationship

Front Cover
Landes, 1996 - Medical - 192 pages
This book is about maternal-fetal interactions during pregnancy that depend on cell surface structures termed HLA. When foreign to the host, HLA stimulate massive graft rejection responses. There is little if any evidence for such a response at the maternal-fetal interface. This may be due to special controls on the expression of HLA in placentas and their associated membranes, which sequester the embryo from maternal immune cells. This book provides the reader with an understanding of HLA and its potential to stimulate graft rejection, describes recent experiments that have provided new insights into HLA gene selection and regulation during development, and discusses the potential implications for fertility in healthy women as well as patients with immune disorders.

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Features of the MaternalFetal Interface
Current Theories on Protection of the Fetal Semiallograft
HLA Class I Genes and Products

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