HLA and the Maternal-Fetal Relationship
This book is about maternal-fetal interactions during pregnancy that depend on cell surface structures termed HLA. When foreign to the host, HLA stimulate massive graft rejection responses. There is little if any evidence for such a response at the maternal-fetal interface. This may be due to special controls on the expression of HLA in placentas and their associated membranes, which sequester the embryo from maternal immune cells. This book provides the reader with an understanding of HLA and its potential to stimulate graft rejection, describes recent experiments that have provided new insights into HLA gene selection and regulation during development, and discusses the potential implications for fertility in healthy women as well as patients with immune disorders.
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Features of the MaternalFetal Interface
Current Theories on Protection of the Fetal Semiallograft
HLA Class I Genes and Products
6 other sections not shown
Acad alleles antibodies arthritis autoimmune disease binding Biol cell surface expression choriocarcinoma chorionic class I antigens class I genes class I heavy class I molecules class lb couples sharing cytokines cytotrophoblast decidual detected domain embryo encoded epithelial cells exon extraembryonic tissues extravillous cytotrophoblast cells factors fertile function Geraghty gestation graft heavy chain HLA antigens HLA class HLA sharing HLA-A HLA-A2/G transgenic HLA-B HLA-C HLA-DR HLA-E HLA-G expressing HLA-G mRNA expression HLA-G protein HLA-G transgenic mice hormones human placenta human trophoblast Hunt Hutterite IFN-y Immunogenet immunological implantation infertility interferon isoforms kb HLA-G transgenic leukocyte loci lymphocytes macrophages major histocompatibility complex membrane MHC antigens MHC class murine NK cells nontransgenic Orr HT peptides placenta polymorphism pregnancy Proc production progesterone prolactin proteasome protein receptors region regulation regulatory secondary RSA sequence soluble specific spontaneous abortion studies subpopulations syncytiotrophoblast tion transfectants transgenic mouse trimester tropho trophoblast cells uterine uterus villous cytotrophoblast vitro